Pregnancy complications associated with hepatitis C: data from a 2003-2005 Washington state birth cohort

Objective The objective of the study was to determine the effect of hepatitis C virus (HCV) on selected maternal and infant birth outcomes. Study Design This population-based cohort study using Washington state birth records from 2003 to 2005 compared a cohort of pregnant women identified as HCV pos...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2008-07, Vol.199 (1), p.38.e1-38.e9
Main Authors: Pergam, Steven A., MD, Wang, Chia C., MD, MS, Gardella, Carolyn M., MD, MPH, Sandison, Taylor G., MD, MPH, Phipps, Warren T., MD, Hawes, Stephen E., PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Mass Index
Cohort Studies
drug use
Female
Gestational Age
gestational diabetes
Gynecology. Andrology. Obstetrics
hepatitis C
Hepatitis C - complications
Human viral diseases
Humans
Infant, Low Birth Weight
Infant, Newborn
Infectious diseases
Medical sciences
Obstetrics and Gynecology
Pregnancy
pregnancy complications
Pregnancy Complications, Infectious
Pregnancy Outcome
Retrospective Studies
Risk Factors
Substance Abuse, Intravenous
United States
Viral diseases
Viral hepatitis
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Summary:Objective The objective of the study was to determine the effect of hepatitis C virus (HCV) on selected maternal and infant birth outcomes. Study Design This population-based cohort study using Washington state birth records from 2003 to 2005 compared a cohort of pregnant women identified as HCV positive from birth certificate data (n = 506) to randomly selected HCV-negative mothers (n = 2022) and drug-using HCV-negative mothers (n = 1439). Results Infants of HCV-positive mothers were more likely to be low birthweight (odds ratio [OR], 2.17; 95% confidence interval [CI] 1.24, 3.80), to be small for gestational age (OR, 1.46; 95% CI, 1.00, 2.13), to need assisted ventilation (OR, 2.37; 95% CI, 1.46, 3.85), and to require neonatal intensive car unit (NICU) admission (OR, 2.91; 95% CI, 1.86, 4.55). HCV-positive mothers with excess weight gain also had a greater risk of gestational diabetes (OR, 2.51; 95% CI, 1.04, 6.03). Compared with the drug-using cohort, NICU admission and the need for assisted ventilation remained associated with HCV. Conclusion HCV-positive pregnant women appear to be at risk for adverse neonatal and maternal outcomes.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2008.03.052