Chronic Intake of a Phytochemical-Enriched Diet Reduces Cardiac Fibrosis and Diastolic Dysfunction Caused by Prolonged Salt-Sensitive Hypertension

Salt-sensitive hypertension is common in the aged population. Increased fruit and vegetable intake reduces hypertension, but its effect on eventual diastolic dysfunction is unknown. This relationship is tested in the Dahl Salt-Sensitive (Dahl-SS) rat model of salt-sensitive hypertension and diastoli...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2008-10, Vol.63 (10), p.1034-1042
Main Authors: Seymour, E. M., Singer, Andrew A. M., Bennink, Maurice R., Parikh, Rushi V., Kirakosyan, Ara, Kaufman, Peter B., Bolling, Steven F.
Format: Article
Language:English
Subjects:
Aging
Alternative medicine
Analysis of Variance
Animals
Diet
Drinking water
Endomyocardial Fibrosis - diet therapy
Endomyocardial Fibrosis - etiology
Endomyocardial Fibrosis - physiopathology
Fruit
Fruits
Heart failure
Heart Failure, Diastolic - diet therapy
Heart Failure, Diastolic - etiology
Heart Failure, Diastolic - physiopathology
Hydralazine - administration & dosage
Hydralazine - pharmacology
Hypertension
Hypertension - etiology
Hypertension - physiopathology
Life sciences
Mortality
Nutrition
Patients
Public health
Random Allocation
Rats
Rats, Inbred Dahl
Sodium Chloride, Dietary - pharmacology
Vegetables
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Summary:Salt-sensitive hypertension is common in the aged population. Increased fruit and vegetable intake reduces hypertension, but its effect on eventual diastolic dysfunction is unknown. This relationship is tested in the Dahl Salt-Sensitive (Dahl-SS) rat model of salt-sensitive hypertension and diastolic dysfunction. Table grape powder contains phytochemicals that are relevant to human diets. For 18 weeks, male Dahl-SS rats were fed one of five diets: low salt (LS), a low salt + grape powder (LSG), high salt (HS), a high salt + grape powder (HSG), or high salt + vasodilator hydralazine (HSH). Compared to the HS diet, the HSG diet lowered blood pressure and improved cardiac function; reduced systemic inflammation; reduced cardiac hypertrophy, fibrosis, and oxidative damage; and increased cardiac glutathione. The HSH diet similarly reduced blood pressure but did not reduce cardiac pathogenesis. The LSG diet reduced cardiac oxidative damage and increased cardiac glutathione. In conclusion, physiologically relevant phytochemical intake reduced salt-sensitive hypertension and diastolic dysfunction.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/63.10.1034