Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Abstract Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi–Cox stained tissue of the basolateral nucleus in young adult (3–5 months) and aged (20–24 months) male and female Long-E...

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Bibliographic Details
Published in:Neurobiology of aging 2009-01, Vol.30 (1), p.137-146
Main Authors: Rubinow, Marisa J, Drogos, Lauren L, Juraska, Janice M
Format: Article
Language:English
Subjects:
Age Factors
Aging
Aging - pathology
Amygdala - pathology
Animals
Basolateral nucleus
Biological and medical sciences
Dendrites
Dendritic spines
Dendritic Spines - pathology
Development. Senescence. Regeneration. Transplantation
Female
Fundamental and applied biological sciences. Psychology
Golgi–Cox
Hypertrophy - pathology
Internal Medicine
Male
Neurology
Rats
Rats, Long-Evans
Sex Characteristics
Sex difference
Sex Factors
Vertebrates: nervous system and sense organs
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Summary:Abstract Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi–Cox stained tissue of the basolateral nucleus in young adult (3–5 months) and aged (20–24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.
ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2007.05.006