Genetic aspects of restless legs syndrome

Restless legs syndrome (RLS), also known as Ekbom syndrome, is a common movement disorder with sensorimotor symptoms occurring during sleep and quiet wakefulness. The underlying cause for RLS is unknown but genetic influences play a strong part in the pathogenesis of RLS, particularly when the condi...

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Bibliographic Details
Published in:Postgraduate medical journal 2006-10, Vol.82 (972), p.626-629
Main Authors: Dhawan, V, Ali, M, Chaudhuri, K R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Mapping
familial
Forecasting
General aspects
Genetic Linkage
genetics
Humans
idiopathic restless legs syndrome
iRLS
LOD
logarithm of odds
MAO
Medical sciences
monoamine oxidase
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
neurotensin
NTS
Pedigree
periodic limb movements in sleep
PLMS
restless legs syndrome
Restless Legs Syndrome - genetics
Review
RLS
SCA
secondary RLS due to uraemia
spinocerebellar ataxia
Spinocerebellar Ataxias - genetics
uRLS
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Description
Summary:Restless legs syndrome (RLS), also known as Ekbom syndrome, is a common movement disorder with sensorimotor symptoms occurring during sleep and quiet wakefulness. The underlying cause for RLS is unknown but genetic influences play a strong part in the pathogenesis of RLS, particularly when the condition starts at a young age. This review explores the genetic basis of RLS and related phenotypic variations. Recently, three loci showing vulnerability to RLS have been described in French-Canadian and Italian families in chromosomes 12q, 14q and 9q, emphasising on an autosomal dominant mode of inheritance. These have been labelled RLS1, RLS2 and RLS3, respectively. However, specific causative mutations remain elusive and no linkage analysis has been identified so far in the candidate genes investigated in RLS.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.2006.045690