Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries

Early age at first sexual intercourse (AFSI) has long been associated with an increased risk of invasive cervical carcinoma (ICC). Age at first pregnancy (AFP) and ICC have been investigated less, although AFSI and AFP are strongly interrelated in most developing countries. A pooled analysis of case...

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Bibliographic Details
Published in:British journal of cancer 2009-04, Vol.100 (7), p.1191-1197
Main Authors: Louie, K S, de Sanjose, S, Diaz, M, Castellsagué, X, Herrero, R, Meijer, C J, Shah, K, Franceschi, S, Muñoz, N, Bosch, F X
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cervical cancer
Developing Countries
Drug Resistance
Epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Maternal Age
Medical sciences
Middle Aged
Molecular Medicine
Oncology
Risk Factors
Sexual Behavior
Tumors
Uterine Cervical Neoplasms - etiology
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Summary:Early age at first sexual intercourse (AFSI) has long been associated with an increased risk of invasive cervical carcinoma (ICC). Age at first pregnancy (AFP) and ICC have been investigated less, although AFSI and AFP are strongly interrelated in most developing countries. A pooled analysis of case–control studies on ICC from eight developing countries with 1864 cases and 1719 controls investigated the roles of AFSI, AFP, and ICC risk. Age at first sexual intercourse, AFP and age at first marriage (AFM) were highly interrelated and had similar ICC risk estimates. Compared with women with AFSI ⩾21 years, the odds ratio (OR) of ICC was 1.80 (95% CI: 1.50–2.39) among women with AFSI 17–20 years and 2.31 (95% CI: 1.85–2.87) for AFSI ⩽16 years ( P -trend
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604974