Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia

Objective: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates. Method: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2006-05, Vol.91 (3), p.F163-F165
Main Authors: Benders, M J N L, Bos, A F, Rademaker, C M A, Rijken, M, Torrance, H L, Groenendaal, F, van Bel, F
Format: Article
Language:English
Subjects:
aEEG
Age
allopurinol
Allopurinol - therapeutic use
amplitude integrated electroencephalogram
Asphyxia Neonatorum - drug therapy
Babies
birth asphyxia
Blood pressure
Brain Ischemia - etiology
Brain Ischemia - prevention & control
Brain research
Double-Blind Method
Enzymes
Free Radical Scavengers - therapeutic use
Free radicals
Free Radicals - adverse effects
Humans
Hypoxia
Infant, Newborn
Infants
magnetic resonance imaging
Mortality
MRI
Neonates
neuroprotection
NMR
Nuclear magnetic resonance
Original
Plasma
reperfusion injury
Reperfusion Injury - etiology
Reperfusion Injury - prevention & control
Studies
Treatment Outcome
Ultrasonic imaging
Variance analysis
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Summary:Objective: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates. Method: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth. Results: The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol. Conclusion: Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2005.086652