Initiation of Oligodendrocyte Progenitor Cell Migration by a PDGF-A Activated Extracellular Regulated Kinase (ERK) Signaling Pathway

During CNS development, oligodendrocyte progenitor (OP) cells migrate from germinal zones to presumptive white matter tracts to generate myelinating oligodendrocytes. In vitro and in vivo studies indicate that platelet-derived growth factor-A (PDGF-A) is a potent chemoattractant for OP cells and imp...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2009-01, Vol.34 (1), p.169-181
Main Authors: Frost, Emma E., Zhou, ZhiCheng, Krasnesky, Kimberley, Armstrong, Regina C.
Format: Article
Language:English
Subjects:
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Movement - physiology
Cell Survival - drug effects
Extracellular Signal-Regulated MAP Kinases - physiology
Feedback, Physiological
Neurochemistry
Neurology
Neurosciences
Oligodendroglia - drug effects
Oligodendroglia - physiology
Original Paper
p38 Mitogen-Activated Protein Kinases - physiology
Phosphatidylinositol 3-Kinases - physiology
Phospholipases A2 - physiology
Platelet-Derived Growth Factor - physiology
Rats
Signal Transduction - physiology
Stem Cells - drug effects
Stem Cells - physiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During CNS development, oligodendrocyte progenitor (OP) cells migrate from germinal zones to presumptive white matter tracts to generate myelinating oligodendrocytes. In vitro and in vivo studies indicate that platelet-derived growth factor-A (PDGF-A) is a potent chemoattractant for OP cells and important for normal distribution throughout the developing CNS. However, PDGF-A does not localize in concentration gradients corresponding to OP migratory pathways, as would be expected for a chemoattractant to direct migration. Therefore, the mechanism by which PDGF-A regulates OP distribution remains to be clarified. Here we show that PDGF-A induces OP migration and continuous exposure to PDGF-A is not required to maintain migration. Using pharmacological inhibitors, we show that a self-sustaining extracellular-regulated-kinase signaling pathway drives OP migration for up to 72 hours after the initial PDGF stimulus. These findings indicate PDGF-A may act to mobilize OP cells that then respond to distinct directional signals to distribute appropriately within the CNS.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-008-9748-z