Adherence to first-line antiretroviral therapy affects non-virologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia

Background High-level adherence to antiretroviral therapy (ART) is associated with favourable patient outcomes. In resource-constrained settings, however, there are few validated measures. We examined the correlation between clinical outcomes and the medication possession ratio (MPR), a pharmacy-bas...

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Bibliographic Details
Published in:International journal of epidemiology 2009-06, Vol.38 (3), p.746-756
Main Authors: Chi, Benjamin H, Cantrell, Ronald A, Zulu, Isaac, Mulenga, Lloyd B, Levy, Jens W, Tambatamba, Bushimbwa C, Reid, Stewart, Mwango, Albert, Mwinga, Alwyn, Bulterys, Marc, Saag, Michael S, Stringer, Jeffrey SA
Format: Article
Language:English
Subjects:
adherence
Adolescent
Adult
Africa
Anti-HIV Agents - therapeutic use
antiretroviral therapy
Antiretroviral Therapy, Highly Active
Biological and medical sciences
CD4-Positive T-Lymphocytes
Female
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV-1
Human viral diseases
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Medication Adherence - statistics & numerical data
medication possession ratio
Medication Therapy Management - statistics & numerical data
Middle Aged
Miscellaneous
mortality
Public health. Hygiene
Public health. Hygiene-occupational medicine
survival
Time Factors
Urban Health
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Young Adult
Zambia
Zambia - epidemiology
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Summary:Background High-level adherence to antiretroviral therapy (ART) is associated with favourable patient outcomes. In resource-constrained settings, however, there are few validated measures. We examined the correlation between clinical outcomes and the medication possession ratio (MPR), a pharmacy-based measure of adherence. Methods We analysed data from a large programmatic cohort across 18 primary care centres providing ART in Lusaka, Zambia. Patients were stratified into three categories based on MPR-calculated adherence over the first 12 months: optimal (≥95%), suboptimal (80–94%) and poor (
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyp004