Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint

The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch res...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2008-04, Vol.14 (4), p.474-479
Main Authors: Burke, Daniel J., Stukenberg, P. Todd
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - physiology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Genes, cdc
Humans
Kinetochores - metabolism
Microtubules - metabolism
Models, Biological
Protein Binding
Protein Kinases - metabolism
Signal Transduction - physiology
Spindle Apparatus - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3
cites cdi_FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3
container_end_page 479
container_issue 4
container_start_page 474
container_title Developmental cell
container_volume 14
creator Burke, Daniel J.
Stukenberg, P. Todd
description The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.
doi_str_mv 10.1016/j.devcel.2008.03.015
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2696048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1534580708001263</els_id><sourcerecordid>69101978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3</originalsourceid><addsrcrecordid>eNp9kE9PGzEQxa0KVNK036CqcuK2y3j_2N4LEkRAUYM4tD1bXu8scdjYwfZG6rfHq0SFXnqyPTPvvfGPkK8UcgqUXWzyDvcah7wAEDmUOdD6A5lRwUVG65qepHtdVlktgJ-RTyFsIMmogI_kjIqKAi_qGblaGfts7NPih7EYnV47j9mD0d7FsR0HXFwb20396BZxjYufu_RO5eUa9fPOGRs_k9NeDQG_HM85-X1782v5PVs93t0vr1aZrgseM1q2ijMGvFUl40J1PdcCFBNYcqY49I1uClo0yIsOGe10rWjVA7QF7bUodTknlwff3dhusdNoo1eD3HmzVf6PdMrIfzvWrOWT28uCNQwqkQzOjwbevYwYotyakAAOyqIbg2RN4trwabA6DCYKIXjs_4ZQkBN7uZEH9nJiL6GUiX2SfXu_4JvoCPvtB5gw7Q16GbRBq7EzHnWUnTP_T3gF-5uYXg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69101978</pqid></control><display><type>article</type><title>Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Burke, Daniel J. ; Stukenberg, P. Todd</creator><creatorcontrib>Burke, Daniel J. ; Stukenberg, P. Todd</creatorcontrib><description>The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2008.03.015</identifier><identifier>PMID: 18410725</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Cycle - physiology ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Genes, cdc ; Humans ; Kinetochores - metabolism ; Microtubules - metabolism ; Models, Biological ; Protein Binding ; Protein Kinases - metabolism ; Signal Transduction - physiology ; Spindle Apparatus - metabolism</subject><ispartof>Developmental cell, 2008-04, Vol.14 (4), p.474-479</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3</citedby><cites>FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18410725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burke, Daniel J.</creatorcontrib><creatorcontrib>Stukenberg, P. Todd</creatorcontrib><title>Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.</description><subject>Animals</subject><subject>Cell Cycle - physiology</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Genes, cdc</subject><subject>Humans</subject><subject>Kinetochores - metabolism</subject><subject>Microtubules - metabolism</subject><subject>Models, Biological</subject><subject>Protein Binding</subject><subject>Protein Kinases - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Spindle Apparatus - metabolism</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kE9PGzEQxa0KVNK036CqcuK2y3j_2N4LEkRAUYM4tD1bXu8scdjYwfZG6rfHq0SFXnqyPTPvvfGPkK8UcgqUXWzyDvcah7wAEDmUOdD6A5lRwUVG65qepHtdVlktgJ-RTyFsIMmogI_kjIqKAi_qGblaGfts7NPih7EYnV47j9mD0d7FsR0HXFwb20396BZxjYufu_RO5eUa9fPOGRs_k9NeDQG_HM85-X1782v5PVs93t0vr1aZrgseM1q2ijMGvFUl40J1PdcCFBNYcqY49I1uClo0yIsOGe10rWjVA7QF7bUodTknlwff3dhusdNoo1eD3HmzVf6PdMrIfzvWrOWT28uCNQwqkQzOjwbevYwYotyakAAOyqIbg2RN4trwabA6DCYKIXjs_4ZQkBN7uZEH9nJiL6GUiX2SfXu_4JvoCPvtB5gw7Q16GbRBq7EzHnWUnTP_T3gF-5uYXg</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Burke, Daniel J.</creator><creator>Stukenberg, P. Todd</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080401</creationdate><title>Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint</title><author>Burke, Daniel J. ; Stukenberg, P. Todd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Cell Cycle - physiology</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Genes, cdc</topic><topic>Humans</topic><topic>Kinetochores - metabolism</topic><topic>Microtubules - metabolism</topic><topic>Models, Biological</topic><topic>Protein Binding</topic><topic>Protein Kinases - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Spindle Apparatus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burke, Daniel J.</creatorcontrib><creatorcontrib>Stukenberg, P. Todd</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burke, Daniel J.</au><au>Stukenberg, P. Todd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>14</volume><issue>4</issue><spage>474</spage><epage>479</epage><pages>474-479</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18410725</pmid><doi>10.1016/j.devcel.2008.03.015</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1534-5807
ispartof Developmental cell, 2008-04, Vol.14 (4), p.474-479
issn 1534-5807
1878-1551
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2696048
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Animals
Cell Cycle - physiology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Genes, cdc
Humans
Kinetochores - metabolism
Microtubules - metabolism
Models, Biological
Protein Binding
Protein Kinases - metabolism
Signal Transduction - physiology
Spindle Apparatus - metabolism
title Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T20%3A41%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Linking%20Kinetochore-Microtubule%20Binding%20to%20the%20Spindle%20Checkpoint&rft.jtitle=Developmental%20cell&rft.au=Burke,%20Daniel%20J.&rft.date=2008-04-01&rft.volume=14&rft.issue=4&rft.spage=474&rft.epage=479&rft.pages=474-479&rft.issn=1534-5807&rft.eissn=1878-1551&rft_id=info:doi/10.1016/j.devcel.2008.03.015&rft_dat=%3Cproquest_pubme%3E69101978%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c527t-13ba76607ba3678adf7c80a68e376a70f9c92129e72de61dc5a14f00b21fc83c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69101978&rft_id=info:pmid/18410725&rfr_iscdi=true