Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro

Microbially mediated reductive dechlorination has been advocated as the first part of a two-stage (anaerobic/aerobic) biotreatment process for polychlorinated biphenyls (PCBs) in sediments, and is generally viewed as a detoxication process. However, previous studies suggest that microbial dechlorina...

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Bibliographic Details
Published in:Environmental research 2008-06, Vol.107 (2), p.185-193
Main Authors: Tsuneta, Taeko, Loch-Caruso, Rita, Quensen, John F., Boyd, Stephen A., Hanna, Mona, Grindatti, Carmen
Format: Article
Language:English
Subjects:
Animals
Aroclor 1260
Aroclors - metabolism
Aroclors - toxicity
Bacteria - metabolism
Biodegradation, Environmental
Biological and medical sciences
Bioremediation
Chemical and industrial products toxicology. Toxic occupational diseases
Environmental Pollutants - metabolism
Environmental Pollutants - toxicity
Female
Freshwater
In Vitro Techniques
Medical sciences
Microbial dechlorination
Polychlorinated biphenyl (PCB)
Pregnancy
Rats
Rats, Sprague-Dawley
Reproduction
Rivers - microbiology
Toxicology
Uterine contraction
Uterine Contraction - drug effects
Various organic compounds
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Summary:Microbially mediated reductive dechlorination has been advocated as the first part of a two-stage (anaerobic/aerobic) biotreatment process for polychlorinated biphenyls (PCBs) in sediments, and is generally viewed as a detoxication process. However, previous studies suggest that microbial dechlorination increases the ability to stimulate uterine contractions compared with the original PCB mixtures. Here, we investigate the composition and uterotonic activity of the commercial PCB mixture Aroclor 1260 before and after incubation with microorganisms eluted from PCB-contaminated sediment of the Hudson River. Incubation with microorganisms resulted in a partially dechlorinated mixture (HR1260) dominated by ortho-substituted PCBs with four or fewer chlorines per biphenyl. Aroclor 1260 that had not been incubated with microorganisms had no significant effect on contraction frequency of rat uterine strips (gestation day 10) in vitro, whereas HR1260 dramatically increased contraction frequency to 718±134% of the basal rate at a total PCB concentration of 70 μM ( p
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2008.01.011