Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine

• Published in: World journal of gastroenterology : WJG 2008-06, Vol.14 (22), p.3574-3578
• Main Authors: Zhang, Min-Jie, Zhang, Guo-Lei, Yuan, Wen-Bin, Ni, Jun, Huang, Li-Feng
• Format: Article
• Language: English
• Subjects: Abdominal Cavity - physiopathology; Acute Disease; Adult; Aged; APACHE; Compartment Syndromes - etiology; Compartment Syndromes - physiopathology; Compartment Syndromes - therapy; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - therapeutic use; Enema; Female; Humans; Hypertension - etiology; Hypertension - physiopathology; Hypertension - therapy; Male; Medicine, Chinese Traditional; Middle Aged; Multiple Organ Failure - etiology; Multiple Organ Failure - physiopathology; Multiple Organ Failure - therapy; Pancreatitis - complications; Plant Extracts; Rapid Communication; Treatment Outcome; 急性胰腺炎; 治疗效果; 腹部疾病
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.3574

AIM： To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction （Timely-Purging and Yin-Preserving Decoction） and Glauber＇s salt combined with conservative measures on abdominal compartment syndrome （ACS） in severe acute pancreatitis （SAP） patients. METHODS： Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group （40 patients in each group）. Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber＇s salt, once a day for 7 d. Patients in the control group received normal saline （NS） enema. Routine non-operative conservative treatments included non-per os nutrition （NPON）, gastrointestinal decompression, life support, total parenteral nutrition （TPN）, continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure （ICP） of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis. RESULTS： On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group（P 〈 0.05）. On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） scores for the study and control groups were significantly different （P 〈 0.05）. Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups （P 〈 0.05）. The mortality rate for the two groups had no significant difference. CONCLUSION： Da Cheng Qi Decoction enema and external use of Glauber＇s salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure （IAP） of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP.