Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men

BACKGROUND Previous studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 (COI) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we e...

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Bibliographic Details
Published in:The Prostate 2009-06, Vol.69 (9), p.956-960
Main Authors: Ray, Anna M., Zuhlke, Kimberly A., Levin, Albert M., Douglas, Julie A., Cooney, Kathleen A., Petros, John A.
Format: Article
Language:English
Subjects:
African Americans - genetics
Aged
association
Biological and medical sciences
COI
Electron Transport Complex IV - genetics
Genetic Predisposition to Disease
Genetic Variation
Gynecology. Andrology. Obstetrics
Haplotypes
Humans
Linkage Disequilibrium
Male
Male genital diseases
Medical sciences
Middle Aged
Mitochondria - enzymology
Mitochondria - genetics
Mutation, Missense
Nephrology. Urinary tract diseases
Polymorphism, Single Nucleotide
prostate cancer
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
SNP
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:BACKGROUND Previous studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 (COI) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we examine the association between COI mutations and PCa in African American men. METHODS The entire COI gene was directly sequenced in 132 PCa cases and 135 controls from the Flint Men's Health Study, a community‐based sample of African American men with and without PCa. Associations between all variants and PCa were evaluated. RESULTS We identified 102 COI single nucleotide polymorphisms (SNPs), including 15 missense variants. Overall, the presence of one or more COI missense variants was not significantly associated with PCa. Individually, two SNPs (T6221C and T7389C) were significantly associated with prostate cancer (P  0.6). CONCLUSIONS Of the two significantly associated SNPs, one is a synonymous substitution and the other is part of the African‐specific mitochondrial haplogroup (L). Additional research will be needed to determine the clinical relevance of these associations in African populations. Prostate 69: 956–960, 2009. © 2009 Wiley‐Liss, Inc.
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.20943