Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture

Introduction Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern simi...

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Published in:Archives of orthopaedic and trauma surgery 2009-10, Vol.129 (10), p.1427-1432
Main Authors: Akritopoulos, Panagiotis, Papaioannidou, Paraskevi, Hatzokos, Ippokratis, Haritanti, Afroditi, Iosifidou, Eirini, Kotoula, Maria, Mirtsou-Fidani, Vassiliki
Format: Article
Language:English
Subjects:
Animals
Basic Science
Cyclooxygenase Inhibitors - pharmacology
Femoral Fractures - diagnostic imaging
Femoral Fractures - surgery
Fracture Fixation, Intramedullary
Fracture Healing - drug effects
Fractures
Hominids
Isoxazoles - pharmacology
Male
Medicine
Medicine & Public Health
Orthopedics
Radiography
Rats
Rats, Wistar
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Summary:Introduction Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern similar to clinical treatment patterns, that is, in a high dose and for a short period after bone fracture. Method Closed non-displaced mid-diaphyseal fractures in the middle of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intra-peritoneally every day for 7 days. In the control group, normal saline was administered intra-peritoneally every day for 7 days. In both groups fracture healing (bone union and callus formation) was evaluated with X-rays 28 and 42 days after surgery. Results Bone healing was lower in the study group (60 vs. 80% in the control group 28 days after fracture and 80 vs. 90% 42 days after fracture) but this difference was not statistically significant ( P  > 0.05). Conclusion Parecoxib does not have a significant long-term effect on bone healing in rats, when it is administered in a high dose and for a short period after bone fracture.
ISSN:0936-8051
1434-3916
DOI:10.1007/s00402-008-0707-6