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ETV5 Is Required for Continuous Spermatogenesis in Adult Mice and May Mediate Blood-Testes Barrier Function and Testicular Immune Privilege
: The transcription factor Ets‐variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self‐renewal, as the targeted deletion of the Etv5 gene in mice (Etv5−/−) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild‐type (WT) and Etv5...
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Published in: | Annals of the New York Academy of Sciences 2007-12, Vol.1120 (1), p.144-151 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | : The transcription factor Ets‐variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self‐renewal, as the targeted deletion of the Etv5 gene in mice (Etv5−/−) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild‐type (WT) and Etv5−/− testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5−/− recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood–testis barrier (Sertoli–Sertoli tight junctional complex) is abnormal in the Etv5−/− mouse. |
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ISSN: | 0077-8923 1749-6632 1930-6547 |
DOI: | 10.1196/annals.1411.005 |