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ETV5 Is Required for Continuous Spermatogenesis in Adult Mice and May Mediate Blood-Testes Barrier Function and Testicular Immune Privilege

: The transcription factor Ets‐variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self‐renewal, as the targeted deletion of the Etv5 gene in mice (Etv5−/−) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild‐type (WT) and Etv5...

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Published in:Annals of the New York Academy of Sciences 2007-12, Vol.1120 (1), p.144-151
Main Authors: MORROW, CARLA M. K., HOSTETLER, CHRIS E., GRISWOLD, MIKE D., HOFMANN, MARIE-CLAUDE, MURPHY, KENNETH M., COOKE, PAUL S., HESS, REX A.
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Language:English
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Summary:: The transcription factor Ets‐variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self‐renewal, as the targeted deletion of the Etv5 gene in mice (Etv5−/−) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild‐type (WT) and Etv5−/− testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5−/− recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood–testis barrier (Sertoli–Sertoli tight junctional complex) is abnormal in the Etv5−/− mouse.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1411.005