Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats

Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical a...

Full description

Saved in:
Bibliographic Details
Published in:Experimental diabetes research 2009-01, Vol.2009 (2009), p.1-12
Main Authors: Hernández-Fonseca, Juan P., Rincón, Jaimar, Pedreañez, Adriana, Viera, Ninoska, Arcaya, José L., Carrizo, Edgardo, Mosquera, Jesús
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Axons - pathology
Causes of
Cerebellum
Cerebellum - ultrastructure
Cerebral cortex
Cerebral Cortex - ultrastructure
Depression
Development and progression
Diabetes
Diabetes Mellitus, Experimental - pathology
Encephalopathy
Health aspects
Hypothalamus
Hypothalamus - ultrastructure
In Situ Nick-End Labeling
Male
Microscopy, Electron, Transmission
Mitochondria - ultrastructure
Mitochondrial Swelling
Myelin Sheath - ultrastructure
Oligodendroglia - ultrastructure
Peripheral nerve diseases
Rats
Rats, Sprague-Dawley
Synapses - ultrastructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral.
ISSN:1687-5214
1687-5303
DOI:10.1155/2009/329632