Reimplantation of avulsed lumbosacral ventral roots in the rat ameliorates injury-induced degeneration of primary afferent axon collaterals in the spinal dorsal columns

Abstract Injuries to the cauda equina/conus medullaris portion of the spinal cord can result in motor, sensory, and autonomic dysfunction, and neuropathic pain. In rats, unilateral avulsion of the motor efferents from the lumbosacral spinal cord results in at-level allodynia, along with a correspond...

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Bibliographic Details
Published in:Neuroscience 2008-03, Vol.152 (2), p.338-345
Main Authors: Bigbee, A.J, Hoang, T.X, Havton, L.A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium-Binding Proteins - metabolism
Cauda Equina - pathology
Cauda Equina - surgery
cauda equina/conus medullaris
Disease Models, Animal
Female
Functional Laterality
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
Indoles
Microfilament Proteins
motor lesion
myelin
Myelin Basic Protein - metabolism
Nerve Degeneration - etiology
Nerve Degeneration - surgery
Nerve Regeneration - physiology
neurofilament
Neurofilament Proteins - metabolism
Neurology
neuroprotection
Rats
Rats, Sprague-Dawley
Recovery of Function - physiology
Replantation - methods
Spinal Cord Injuries - complications
Spinal Cord Injuries - pathology
Spinal Cord Injuries - surgery
spinal cord injury
Spinal Nerve Roots - surgery
Vertebrates: nervous system and sense organs
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Summary:Abstract Injuries to the cauda equina/conus medullaris portion of the spinal cord can result in motor, sensory, and autonomic dysfunction, and neuropathic pain. In rats, unilateral avulsion of the motor efferents from the lumbosacral spinal cord results in at-level allodynia, along with a corresponding glial and inflammatory response in the dorsal horn of the spinal cord segments immediately rostral to the lesion. Here, we investigated the fate of intramedullary primary sensory projections following a motor efferent lesion. The lumbosacral (L6 and S1) ventral roots were unilaterally avulsed from the rat spinal cord (VRA; n =9). A second experimental group had the avulsed roots acutely reimplanted into the lateral funiculus (Imp; n =5), as this neural repair strategy is neuroprotective, and promotes the functional reinnervation of peripheral targets. A laminectomy-only group served as controls (Lam; n =7). At 8 weeks post-lesion, immunohistochemical examination showed a 42% reduction ( P
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2007.11.043