Catalytic Enantioselective Alkylation of Substituted Dioxanone Enol Ethers: Ready Access to C(α)-Tetrasubstituted Hydroxyketones, Acids, and Esters

Adaptive Alkylation: Palladium‐catalyzed asymmetric alkylation enables access to fully substituted enantioenriched oxygenated stereocenters, which can be transformed easily to α‐hydroxyketones, esters, and acids, providing a catalytic, enantioselective synthesis for natural products.

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6873-6876
Main Authors: Seto, Masaki, Roizen, Jennifer L, Stoltz, Brian M
Format: Article
Language:English
Subjects:
alcohols
allylic compounds
asymmetric catalysis
enantioselectivity
palladium
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Description
Summary:Adaptive Alkylation: Palladium‐catalyzed asymmetric alkylation enables access to fully substituted enantioenriched oxygenated stereocenters, which can be transformed easily to α‐hydroxyketones, esters, and acids, providing a catalytic, enantioselective synthesis for natural products.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801424