Factors Associated with Serum Retinol, α-Tocopherol, Carotenoids, and Selenium in Hispanics with Problems of HIV, Chronic Hepatitis C, and Drug Use

The effects of hepatitis and drug use on nutritional problems in HIV infection have rarely been examined despite the importance of drug use in the global HIV pandemic. We examined the effects of HIV, hepatitis C, and drug use on serum micronutrients in 300 US Hispanic adults. Chronic hepatitis C inf...

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Bibliographic Details
Published in:Journal of public health policy 2009-09, Vol.30 (3), p.285-299
Main Authors: Forrester, Janet E., Wang, Xiang D., Knox, Tamsin A., Borek, Carmia G., Tang, Alice M., Johnson, Elizabeth J.
Format: Article
Language:English
Subjects:
Adult
AIDS
alpha-Tocopherol - blood
Carotenoids
Carotenoids - blood
Cohort Studies
Equality and Human Rights
Female
Health policy
Hepatitis C, Chronic - physiopathology
Hispanic Americans
HIV
HIV infections
HIV Infections - physiopathology
Humans
Infections
Male
Medical Sociology
Micronutrients
Middle Aged
Original Article
Public Health
Selenium
Selenium - blood
Social Justice
Social Policy
Social Sciences
Sociology
Substance-Related Disorders - physiopathology
United States
Vitamin A
Vitamin A - blood
Vitamin E
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Summary:The effects of hepatitis and drug use on nutritional problems in HIV infection have rarely been examined despite the importance of drug use in the global HIV pandemic. We examined the effects of HIV, hepatitis C, and drug use on serum micronutrients in 300 US Hispanic adults. Chronic hepatitis C infection was associated with lower serum retinol (— 8.2µg/dl, P< 0.0001), α-tocopherol (-0.10 ln µg/dl, P = 0.024), and carotenoids (-19.8 µg/dl, P< 0.0001). HIV infection was associated with lower selenium (-6.1µg/l, P = 0.028). Elevated triglycérides in HIV infection were associated with higher serum retinol and α-tocopherol. Drug use was not independently associated with micronutrient alterations. We conclude that hepatitis C is an important determinant of low serum micronutrients, and should be considered in any nutritional assessment of HIV infected populations. As the safety of micronutrient supplementation is not established, policy for appropriate HIV clinical care should distinguish between populations with and without hepatitis coinfection.
ISSN:0197-5897
1745-655X
DOI:10.1057/jphp.2009.20