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Salivary analysis of oral cancer biomarkers
Background: Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing. Methods: We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers relat...
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| Published in: | British journal of cancer 2009-10, Vol.101 (7), p.1194-1198 |
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| container_end_page | 1198 |
| container_issue | 7 |
| container_start_page | 1194 |
| container_title | British journal of cancer |
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| creator | Shpitzer, T Hamzany, Y Bahar, G Feinmesser, R Savulescu, D Borovoi, I Gavish, M Nagler, R M |
| description | Background:
Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing.
Methods:
We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers related to oxidative stress, DNA repair, carcinogenesis, metastasis and cellular proliferation and death.
Results:
Five markers increased in cancer patients by 39–246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 and Cyclin D1 (CycD1) (
P
⩽0.01). Three markers decreased by 16–29%: 8-oxoguanine DNA glycosylase, phosphorylated-Src and mammary serine protease inhibitor (Maspin) (
P
⩽0.01). Increase in salivary carbonyls was profound (by 246%,
P
=0.012); alterations in CycD1 (87% increase,
P
=0.000006) and Maspin (29% decrease,
P
=0.007) were especially significant. Sensitivity values of these eight analysed markers ranged from 58% to 100%; specificity values ranged from 42% to 100%. Both values were especially high for the CycD1 and Maspin markers, 100% for each value of each marker. These were also high for carbonyls, 90% and 80%, respectively, and for MMP-9, 100% and 79%, respectively.
Conclusion:
The significance of each salivary alteration is discussed. As all alterations correlated with each other, they may belong to a single carcinogenetic network. Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring. |
| doi_str_mv | 10.1038/sj.bjc.6605290 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1878200241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-1a4b109f94722fea6a2b45be23cb11e89f360c4252dcb5d5b6b9fd505d593db03</originalsourceid><addsrcrecordid>eNp1kM9LwzAUx4Mobk6v3pQieJJ2L2nTJhdBhr9g4EE9hyRNZ2vXzqQd7L83sjr14CkvvM_7vu_7InSKIcIQs6mrIlXpKE2BEg57aIxpTELMSLaPxgCQhcAJjNCRc5X_cmDZIRphnjFOYzpGV8-yLtfSbgLZyHrjShe0RdBaWQdaNtrYQJXtUtp3Y90xOihk7czJ8E7Q693ty-whnD_dP85u5qGmkHUhlonCwAueZIQURqaSqIQqQ2KtMDaMF3EKOiGU5FrRnKpU8SKn4Ese5wriCbre6q56tTS5Nk3n_YiVLb2RjWhlKf52mvJNLNq1IFnKgDMvcDEI2PajN64TVdtbf58ThHDOwF_voWgLads6Z02xW4BBfGUrXCV8tmLI1g-c_7b1gw9heuByAKTTsi6sD7B0O44QDCRNYs9Nt5zzrWZh7I-9f1efbSca2fXW7CS_-5_GvZxi</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229980789</pqid></control><display><type>article</type><title>Salivary analysis of oral cancer biomarkers</title><source>Open Access: PubMed Central</source><creator>Shpitzer, T ; Hamzany, Y ; Bahar, G ; Feinmesser, R ; Savulescu, D ; Borovoi, I ; Gavish, M ; Nagler, R M</creator><creatorcontrib>Shpitzer, T ; Hamzany, Y ; Bahar, G ; Feinmesser, R ; Savulescu, D ; Borovoi, I ; Gavish, M ; Nagler, R M</creatorcontrib><description>Background:
Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing.
Methods:
We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers related to oxidative stress, DNA repair, carcinogenesis, metastasis and cellular proliferation and death.
Results:
Five markers increased in cancer patients by 39–246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 and Cyclin D1 (CycD1) (
P
⩽0.01). Three markers decreased by 16–29%: 8-oxoguanine DNA glycosylase, phosphorylated-Src and mammary serine protease inhibitor (Maspin) (
P
⩽0.01). Increase in salivary carbonyls was profound (by 246%,
P
=0.012); alterations in CycD1 (87% increase,
P
=0.000006) and Maspin (29% decrease,
P
=0.007) were especially significant. Sensitivity values of these eight analysed markers ranged from 58% to 100%; specificity values ranged from 42% to 100%. Both values were especially high for the CycD1 and Maspin markers, 100% for each value of each marker. These were also high for carbonyls, 90% and 80%, respectively, and for MMP-9, 100% and 79%, respectively.
Conclusion:
The significance of each salivary alteration is discussed. As all alterations correlated with each other, they may belong to a single carcinogenetic network. Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6605290</identifier><identifier>PMID: 19789535</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies ; Biochemistry ; Biological and medical sciences ; Biomarkers ; Biomarkers, Tumor - analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Squamous Cell - diagnosis ; Cyclin D1 - analysis ; Dehydrogenases ; DNA Glycosylases - analysis ; Drug Resistance ; Epidemiology ; Female ; Humans ; Ki-67 Antigen - analysis ; Male ; Matrix Metalloproteinase 9 - analysis ; Medical research ; Medical sciences ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Staging ; Oncology ; Oral cancer ; Otolaryngology ; Otorhinolaryngology. Stomatology ; Saliva - chemistry ; Sensitivity and Specificity ; Tongue ; Tongue Neoplasms - diagnosis ; Tongue Neoplasms - pathology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>British journal of cancer, 2009-10, Vol.101 (7), p.1194-1198</ispartof><rights>The Author(s) 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 6, 2009</rights><rights>Copyright © 2009 Cancer Research UK 2009 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-1a4b109f94722fea6a2b45be23cb11e89f360c4252dcb5d5b6b9fd505d593db03</citedby><cites>FETCH-LOGICAL-c507t-1a4b109f94722fea6a2b45be23cb11e89f360c4252dcb5d5b6b9fd505d593db03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768098/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768098/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22102643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19789535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shpitzer, T</creatorcontrib><creatorcontrib>Hamzany, Y</creatorcontrib><creatorcontrib>Bahar, G</creatorcontrib><creatorcontrib>Feinmesser, R</creatorcontrib><creatorcontrib>Savulescu, D</creatorcontrib><creatorcontrib>Borovoi, I</creatorcontrib><creatorcontrib>Gavish, M</creatorcontrib><creatorcontrib>Nagler, R M</creatorcontrib><title>Salivary analysis of oral cancer biomarkers</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing.
Methods:
We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers related to oxidative stress, DNA repair, carcinogenesis, metastasis and cellular proliferation and death.
Results:
Five markers increased in cancer patients by 39–246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 and Cyclin D1 (CycD1) (
P
⩽0.01). Three markers decreased by 16–29%: 8-oxoguanine DNA glycosylase, phosphorylated-Src and mammary serine protease inhibitor (Maspin) (
P
⩽0.01). Increase in salivary carbonyls was profound (by 246%,
P
=0.012); alterations in CycD1 (87% increase,
P
=0.000006) and Maspin (29% decrease,
P
=0.007) were especially significant. Sensitivity values of these eight analysed markers ranged from 58% to 100%; specificity values ranged from 42% to 100%. Both values were especially high for the CycD1 and Maspin markers, 100% for each value of each marker. These were also high for carbonyls, 90% and 80%, respectively, and for MMP-9, 100% and 79%, respectively.
Conclusion:
The significance of each salivary alteration is discussed. As all alterations correlated with each other, they may belong to a single carcinogenetic network. Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Cyclin D1 - analysis</subject><subject>Dehydrogenases</subject><subject>DNA Glycosylases - analysis</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - analysis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Saliva - chemistry</subject><subject>Sensitivity and Specificity</subject><subject>Tongue</subject><subject>Tongue Neoplasms - diagnosis</subject><subject>Tongue Neoplasms - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kM9LwzAUx4Mobk6v3pQieJJ2L2nTJhdBhr9g4EE9hyRNZ2vXzqQd7L83sjr14CkvvM_7vu_7InSKIcIQs6mrIlXpKE2BEg57aIxpTELMSLaPxgCQhcAJjNCRc5X_cmDZIRphnjFOYzpGV8-yLtfSbgLZyHrjShe0RdBaWQdaNtrYQJXtUtp3Y90xOihk7czJ8E7Q693ty-whnD_dP85u5qGmkHUhlonCwAueZIQURqaSqIQqQ2KtMDaMF3EKOiGU5FrRnKpU8SKn4Ese5wriCbre6q56tTS5Nk3n_YiVLb2RjWhlKf52mvJNLNq1IFnKgDMvcDEI2PajN64TVdtbf58ThHDOwF_voWgLads6Z02xW4BBfGUrXCV8tmLI1g-c_7b1gw9heuByAKTTsi6sD7B0O44QDCRNYs9Nt5zzrWZh7I-9f1efbSca2fXW7CS_-5_GvZxi</recordid><startdate>20091006</startdate><enddate>20091006</enddate><creator>Shpitzer, T</creator><creator>Hamzany, Y</creator><creator>Bahar, G</creator><creator>Feinmesser, R</creator><creator>Savulescu, D</creator><creator>Borovoi, I</creator><creator>Gavish, M</creator><creator>Nagler, R M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20091006</creationdate><title>Salivary analysis of oral cancer biomarkers</title><author>Shpitzer, T ; Hamzany, Y ; Bahar, G ; Feinmesser, R ; Savulescu, D ; Borovoi, I ; Gavish, M ; Nagler, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-1a4b109f94722fea6a2b45be23cb11e89f360c4252dcb5d5b6b9fd505d593db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Cyclin D1 - analysis</topic><topic>Dehydrogenases</topic><topic>DNA Glycosylases - analysis</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - analysis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Saliva - chemistry</topic><topic>Sensitivity and Specificity</topic><topic>Tongue</topic><topic>Tongue Neoplasms - diagnosis</topic><topic>Tongue Neoplasms - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shpitzer, T</creatorcontrib><creatorcontrib>Hamzany, Y</creatorcontrib><creatorcontrib>Bahar, G</creatorcontrib><creatorcontrib>Feinmesser, R</creatorcontrib><creatorcontrib>Savulescu, D</creatorcontrib><creatorcontrib>Borovoi, I</creatorcontrib><creatorcontrib>Gavish, M</creatorcontrib><creatorcontrib>Nagler, R M</creatorcontrib><collection>Springer_OA刊</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shpitzer, T</au><au>Hamzany, Y</au><au>Bahar, G</au><au>Feinmesser, R</au><au>Savulescu, D</au><au>Borovoi, I</au><au>Gavish, M</au><au>Nagler, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary analysis of oral cancer biomarkers</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2009-10-06</date><risdate>2009</risdate><volume>101</volume><issue>7</issue><spage>1194</spage><epage>1198</epage><pages>1194-1198</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing.
Methods:
We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers related to oxidative stress, DNA repair, carcinogenesis, metastasis and cellular proliferation and death.
Results:
Five markers increased in cancer patients by 39–246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 and Cyclin D1 (CycD1) (
P
⩽0.01). Three markers decreased by 16–29%: 8-oxoguanine DNA glycosylase, phosphorylated-Src and mammary serine protease inhibitor (Maspin) (
P
⩽0.01). Increase in salivary carbonyls was profound (by 246%,
P
=0.012); alterations in CycD1 (87% increase,
P
=0.000006) and Maspin (29% decrease,
P
=0.007) were especially significant. Sensitivity values of these eight analysed markers ranged from 58% to 100%; specificity values ranged from 42% to 100%. Both values were especially high for the CycD1 and Maspin markers, 100% for each value of each marker. These were also high for carbonyls, 90% and 80%, respectively, and for MMP-9, 100% and 79%, respectively.
Conclusion:
The significance of each salivary alteration is discussed. As all alterations correlated with each other, they may belong to a single carcinogenetic network. Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19789535</pmid><doi>10.1038/sj.bjc.6605290</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of cancer, 2009-10, Vol.101 (7), p.1194-1198 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768098 |
| source | Open Access: PubMed Central |
| subjects | Adult Aged Aged, 80 and over Antibodies Biochemistry Biological and medical sciences Biomarkers Biomarkers, Tumor - analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - diagnosis Cyclin D1 - analysis Dehydrogenases DNA Glycosylases - analysis Drug Resistance Epidemiology Female Humans Ki-67 Antigen - analysis Male Matrix Metalloproteinase 9 - analysis Medical research Medical sciences Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Staging Oncology Oral cancer Otolaryngology Otorhinolaryngology. Stomatology Saliva - chemistry Sensitivity and Specificity Tongue Tongue Neoplasms - diagnosis Tongue Neoplasms - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Salivary analysis of oral cancer biomarkers |
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