Group of signs: a new method to evaluate glycemic variability

• Published in: Journal of diabetes science and technology 2008-11, Vol.2 (6), p.1061-1065
• Main Authors: Zaccardi, Francesco, Stefano, Paola Di, Busetto, Elena, Federici, Marco Orsini, Manto, Andrea, Infusino, Fabio, Lanza, Gaetano Antonio, Pitocco, Dario, Ghirlanda, Giovanni
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1932-2968; 1932-3107
• DOI: 10.1177/193229680800200614

Glycemic variability is an important parameter used to resolve potential clinical problems in diabetic patients. It is known that glycemic variability generates oxidative stress and potentially contributes to the development of macro- and microvascular complications in diabetes. By controlling glycemic variability, it is possible to reduce these complications and to set the therapy for all patients with diabetes. The aims of this study were to (1) propose a new standardized, objective, and flexible approach to measure glycemic variability by a continuous glucose monitoring system (CGMS)-the group of signs (GOS) method; (2) compare the correlation between mean amplitude of glucose excursion (MAGE), a well-known index of glycemic variability calculated by the physician and the MAGE defined with the GOS method, in order to validate the GOS; and (3) suggest new indexes of glycemic variability. We tested the GOS algorithm on data collected by a CGMS every 5 minutes for 24 hours on 50 patients. Consequently, for 8 patients we calculated and compared the physician's MAGE in the standard way and by the GOS method. Comparison between the two methods has shown high correlations, from a minimum correlation of 86% to a maximum of 98%, with p values