Renal elimination of organic anions in cholestasis

The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic and endogenous organic anion secretion. It is well known that...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2008-11, Vol.14 (43), p.6616-6621
Main Author: Torres, Adriana Monica
Format: Article
Language:English
Subjects:
Anions - metabolism
Cholestasis, Extrahepatic - metabolism
Drug-Related Side Effects and Adverse Reactions - prevention & control
Humans
Kidney - metabolism
Kidney Tubules, Proximal - metabolism
Organic Anion Transport Protein 1 - metabolism
Organic Anion Transporters - metabolism
Organic Anion Transporters, Sodium-Independent - metabolism
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Summary:The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic and endogenous organic anion secretion. It is well known that cholestasis may cause renal damage. Impairment of kidney function produces modifications in the renal elimination of drugs. Recent studies have demonstrated that the renal abundance of OAT1 and OAT3 plays an important role in the renal elimination of organic anions in the presence of extrahepatic cholestasis. Time elapsed after obstructive cholestasis has an important impact on the regulation of both types of organic anion transporters. The renal expression of OAT1 and OAT3 should be taken into account in order to improve pharmacotherapeutic efficacy and to prevent drug toxicity during the onset of this hepatic disease.
ISSN:1007-9327
DOI:10.3748/wjg.14.6616