Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review

To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria. This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2008-11, Vol.14 (42), p.6531-6535
Main Authors: Abdulkareem, Fatimah-Biade, Abudu, Emmanuel-Kunle, Awolola, Nicholas-Awodele, Elesha, Stephen-Olafimihan, Rotimi, Olorunda, Akinde, Olakanmi-Raphael, Atoyebi, Ayoola-Oluwole, Adesanya, Adedoyin-Adekunle, Daramola, Adetola-Olubunmi, Banjo, Adekumbiola-Aina-Fehintola, Anunobi, Charles-Chidozie
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma, Mucinous - epidemiology
Adenocarcinoma, Mucinous - pathology
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Carcinoma - epidemiology
Carcinoma - pathology
Carcinoma, Signet Ring Cell - epidemiology
Carcinoma, Signet Ring Cell - pathology
Cell Differentiation
Child
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - pathology
Female
Humans
Male
Middle Aged
Neoplasm Staging
Nigeria - epidemiology
Rapid Communication
Retrospective Studies
Sex Distribution
Young Adult
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Summary:To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria. This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study. There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively. CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
ISSN:1007-9327
DOI:10.3748/wjg.14.6531