Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes

• Published in: American journal of obstetrics and gynecology 2009-10, Vol.201 (4), p.402.e1-402.e5
• Main Authors: Laughon, S. Katherine, MD, MS, Catov, Janet, PhD, Provins, Traci, Roberts, James M., MD, Gandley, Robin E., PhD
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Body Mass Index; Diabetes, Gestational - blood; Diabetes, Gestational - epidemiology; Female; gestational diabetes; Gynecology. Andrology. Obstetrics; Humans; hyperuricemia; Hyperuricemia - epidemiology; Insulin Resistance - physiology; Logistic Models; Medical sciences; Obstetrics and Gynecology; Pregnancy; Pregnancy Trimester, First - blood; ROC Curve; uric acid; Uric Acid - blood
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2009.06.065

Objective We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM). Study Design Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8.9 ± 2.5 weeks. The primary outcome was GDM, diagnosed by 3-hour glucose tolerance test using Carpenter and Coustan criteria or by a 1-hour value of ≥200 mg/dL. Logistic regression was performed, adjusting for relevant covariates. Results Almost half (46.6%) of the women with GDM had first-trimester uric acid concentrations in the highest quartile (>3.57-8.30 mg/dL). Women with uric acid in the highest quartile had a 3.25-fold increased risk (95% confidence interval, 1.35–7.83) of developing GDM after adjustment for body mass index and age. This effect was concentration dependent as risk increased with increasing uric acid quartiles ( P = .003). Conclusion First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index.