Reduced Ratio of Afferent to Total Vascular Density in Mesial Temporal Sclerosis

Mesial temporal sclerosis (MTS) is the most common cause of drug-resistant temporal lobe epilepsy in adults. Despite nearly 2 centuries since the first reports of MTS, relatively little is known about its etiology and pathogenesis. Increasing attention has been directed toward the potential role of...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2009-10, Vol.68 (10), p.1147-1154
Main Authors: Mott, Ryan T, Thore, Clara R, Moody, Dixon M, Glazier, Steven S, Ellis, Thomas L, Brown, William R
Format: Article
Language:English
Subjects:
Adult
Aging - metabolism
Aging - pathology
Alkaline Phosphatase - metabolism
Biological and medical sciences
CA2 Region, Hippocampal - blood supply
CA2 Region, Hippocampal - metabolism
CA2 Region, Hippocampal - pathology
CA3 Region, Hippocampal - blood supply
CA3 Region, Hippocampal - metabolism
CA3 Region, Hippocampal - pathology
Cell Death
Collagen Type IV - metabolism
Hippocampus - blood supply
Hippocampus - metabolism
Hippocampus - pathology
Humans
Medical sciences
Microvessels - metabolism
Microvessels - pathology
Middle Aged
Neurology
Neurons - pathology
Sclerosis - pathology
Temporal Lobe - blood supply
Temporal Lobe - metabolism
Temporal Lobe - pathology
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Summary:Mesial temporal sclerosis (MTS) is the most common cause of drug-resistant temporal lobe epilepsy in adults. Despite nearly 2 centuries since the first reports of MTS, relatively little is known about its etiology and pathogenesis. Increasing attention has been directed toward the potential role of vascular abnormalities in MTS. We evaluated the hippocampal microvasculature in 9 MTS cases and 3 non-MTS controls using celloidin tissue sections and markers for total (collagen type IV) and afferent (enzymatic alkaline phosphatase) vessels. Tissue sections were assessed by light microscopy and quantified by threshold analysis of digital images and stereological analysis using the Space Balls probe. Although consistent alterations in the total microvascular density were not found, there was a significant reduction in the density of afferent vessels using both methodologies; these reductions were in areas CA2 and CA3 by image threshold analysis and in area CA3 using stereological measures of the ratio of afferent to total vessels. Increased numbers of string vessels (i.e. remnants of regressing vasculature) were also observed in Ammon's horn, suggesting vascular degeneration in the MTS hippocampus. These findings may help further our understanding of the pathophysiology of MTS.
ISSN:0022-3069
1554-6578
DOI:10.1097/NEN.0b013e3181b9d75f