Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

This study is an extrapolation of our previous one (part I) concerned with the formulation and physicochemical evaluation of a novel, simple, monolayer, easy-to-use, cost-effective, and aesthetically acceptable bioadhesive transdermal patch for tramadol hydrochloride. The current work is focused on...

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Bibliographic Details
Published in:AAPS PharmSciTech 2009-09, Vol.10 (3), p.1065-1070, Article 1065
Main Authors: Ammar, Hussein O., Ghorab, Mahmoud, El-Nahhas, Soheir A., Kamel, Rabab
Format: Article
Language:English
Subjects:
Adhesiveness
Administration, Cutaneous
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - chemistry
Analgesics, Opioid - pharmacology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chemistry, Pharmaceutical
Chitosan
Delayed-Action Preparations
Drug Carriers
Drug Delivery Systems
Irritants - toxicity
Male
Mice
Pain Measurement - drug effects
Pharmacology/Toxicology
Pharmacy
Polymers
Polymethacrylic Acids
Rats
Rats, Wistar
Research Article
Skin - chemistry
Skin - cytology
Tramadol - administration & dosage
Tramadol - chemistry
Tramadol - pharmacology
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Summary:This study is an extrapolation of our previous one (part I) concerned with the formulation and physicochemical evaluation of a novel, simple, monolayer, easy-to-use, cost-effective, and aesthetically acceptable bioadhesive transdermal patch for tramadol hydrochloride. The current work is focused on bioadhesion, skin tolerability, and pharmacodynamic evaluation. Using naked rat skin, chitosan–Eudragit® NE30D (1:1) film attained best bioadhesive properties. During in vivo studies, it also showed a significantly extended analgesic effect compared to both oral formula and chitosan single polymeric film using the hot plate test method. All the polymeric films were skin tolerable for the intended period of application according to the Draize test. The success of our approach can proudly, positively contribute into the world of pain management and arguably push transdermal delivery to realize its great promise.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-009-9294-2