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Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians
Aboriginal communities in Northern Australia with high rates of group A streptococcal (GAS) skin infection in childhood also have high rates of renal failure in adult life. In a cross-sectional study of one such high risk community, albuminuria was used as a marker of renal disease. The prevalence o...
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| Published in: | Epidemiology and infection 1999-02, Vol.122 (1), p.67-75 |
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| container_title | Epidemiology and infection |
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| creator | GOODFELLOW, A. M. HOY, W. E. SRIPRAKASH, K. S. DALY, M. J. REEVE, M. P. MATHEWS, J. D. |
| description | Aboriginal communities in Northern Australia with high rates of
group A streptococcal (GAS)
skin infection in childhood also have high rates of renal failure in adult
life. In a cross-sectional study of one such high risk community, albuminuria was used as
a marker of renal
disease. The prevalence of albuminuria increased from 0/52 in subjects
aged 10–19 years to
10/29 (32·9%) in those aged 50 or more (P |
| doi_str_mv | 10.1017/S0950268898001812 |
| format | article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2809589</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0950268898001812</cupid><jstor_id>3865236</jstor_id><sourcerecordid>3865236</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-7278536eda07b15b31b4631fc61f3e8e9e447cb33375dc8815621abc731a843b3</originalsourceid><addsrcrecordid>eNqFkV1rFDEUhoModlv9AYJILsS70WQy-boR1qJVXL-oXockk9lmOzuZJplq_71ZZ1krgkIgIe9zXs45LwCPMHqOEeYvzpGkqGZCSIEQFri-Axa4YbJqGiTvgsVOrnb6EThOaYMQkrXg98ERLi_BBV-Ay88xZOeHKXoNfYI6pWC9zq6F332-gKOLyafsButg6KAesjehvYE5wJSjG3OwwVrdww9wnJ1gOUsTol_7ofwvp8Lp3ushPQD3Ot0n93B_n4Bvb15_PX1brT6dvTtdripLMc0Vr7mghLlWI24wNQSbhhHcWYY74oSTrmm4NYQQTlsrBKasxtpYTrAWDTHkBLycfcfJbF1r3bDrQI3Rb3W8UUF79acy-Au1DteqFmVjQhaDZ3uDGK4ml7La-mRd3-vBhSkpJhklCNf_BTGvqZSSFBDPoI0hpei6QzcYqV2W6q8sS82T22PcqpjDK8DTPaBTiaCLerA-_eY4luQX9njGNimHeJCJYLQmrMjVLO9i_nGQdbxUjJcVK3b2Ra3OCXn18T1TTeHJfhS9NdG3a6c2YYol6_SPYX4CD5jQTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17259993</pqid></control><display><type>article</type><title>Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Cambridge University Press</source><source>PubMed Central</source><creator>GOODFELLOW, A. M. ; HOY, W. E. ; SRIPRAKASH, K. S. ; DALY, M. J. ; REEVE, M. P. ; MATHEWS, J. D.</creator><creatorcontrib>GOODFELLOW, A. M. ; HOY, W. E. ; SRIPRAKASH, K. S. ; DALY, M. J. ; REEVE, M. P. ; MATHEWS, J. D.</creatorcontrib><description>Aboriginal communities in Northern Australia with high rates of
group A streptococcal (GAS)
skin infection in childhood also have high rates of renal failure in adult
life. In a cross-sectional study of one such high risk community, albuminuria was used as
a marker of renal
disease. The prevalence of albuminuria increased from 0/52 in subjects
aged 10–19 years to
10/29 (32·9%) in those aged 50 or more (P<0·001).
Antibodies to streptococcal M protein,
markers of past GAS infection, were present in 48/52 (92%) at ages
10–19 years, 16/32 (50%)
at ages 30–39, and 20/29 (69%) in those aged 50 or more. After
allowing for the age-dependencies of albuminuria and of M protein antibodies (P<0·001)
albuminuria was
significantly associated with M protein antibodies (P<0·01).
Thus, 72% of adults aged 30 or
more with M protein antibodies also had albuminuria, compared with only
21% of those who
were seronegative. More detailed modelling suggested that although most
Aboriginal people in
this community developed M protein antibodies following GAS infection in
childhood, the
development of proteinuria was associated with the persistence of such
seropositivity into adult
life. The models predicted that proteinuria developed at a mean age of
30 years in seropositive
persons, at 45 years in seronegative persons who were overweight, and at
62 years in
seronegative persons of normal weight. We demonstrated a clear association
between evidence
of childhood GAS infection and individual risk of proteinuria in adult
life. This study provided
a strong rationale for prevention of renal disease through the more effective
control of GAS
skin infections in childhood and through the prevention of obesity in adult
life.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268898001812</identifier><identifier>PMID: 10098787</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Age distribution ; Albuminuria ; Albuminuria - immunology ; Albuminuria - microbiology ; Antibodies ; Antibodies, Bacterial - blood ; Antigens, Bacterial ; Bacterial diseases ; Bacterial Outer Membrane Proteins ; Bacteriology ; Biological and medical sciences ; Carrier Proteins ; Child ; Childhood ; Connectin ; Cross-Sectional Studies ; Diabetic nephropathies ; Endemic Diseases - statistics & numerical data ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Glomerulonephritis ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Kidney Failure, Chronic - microbiology ; Medical sciences ; Microbiology ; Middle Aged ; Muscle Proteins ; Myeloma Proteins ; Northern Territory ; Obesity - complications ; Overweight ; Prospective Studies ; Proteinuria ; Regression Analysis ; Risk Factors ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcal Infections - complications ; Streptococcus ; Streptococcus pyogenes - immunology</subject><ispartof>Epidemiology and infection, 1999-02, Vol.122 (1), p.67-75</ispartof><rights>1999 Cambridge University Press</rights><rights>Copyright 1999 Cambridge University Press</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-7278536eda07b15b31b4631fc61f3e8e9e447cb33375dc8815621abc731a843b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3865236$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0950268898001812/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771,58216,58449,72706</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1719387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10098787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOODFELLOW, A. M.</creatorcontrib><creatorcontrib>HOY, W. E.</creatorcontrib><creatorcontrib>SRIPRAKASH, K. S.</creatorcontrib><creatorcontrib>DALY, M. J.</creatorcontrib><creatorcontrib>REEVE, M. P.</creatorcontrib><creatorcontrib>MATHEWS, J. D.</creatorcontrib><title>Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Aboriginal communities in Northern Australia with high rates of
group A streptococcal (GAS)
skin infection in childhood also have high rates of renal failure in adult
life. In a cross-sectional study of one such high risk community, albuminuria was used as
a marker of renal
disease. The prevalence of albuminuria increased from 0/52 in subjects
aged 10–19 years to
10/29 (32·9%) in those aged 50 or more (P<0·001).
Antibodies to streptococcal M protein,
markers of past GAS infection, were present in 48/52 (92%) at ages
10–19 years, 16/32 (50%)
at ages 30–39, and 20/29 (69%) in those aged 50 or more. After
allowing for the age-dependencies of albuminuria and of M protein antibodies (P<0·001)
albuminuria was
significantly associated with M protein antibodies (P<0·01).
Thus, 72% of adults aged 30 or
more with M protein antibodies also had albuminuria, compared with only
21% of those who
were seronegative. More detailed modelling suggested that although most
Aboriginal people in
this community developed M protein antibodies following GAS infection in
childhood, the
development of proteinuria was associated with the persistence of such
seropositivity into adult
life. The models predicted that proteinuria developed at a mean age of
30 years in seropositive
persons, at 45 years in seronegative persons who were overweight, and at
62 years in
seronegative persons of normal weight. We demonstrated a clear association
between evidence
of childhood GAS infection and individual risk of proteinuria in adult
life. This study provided
a strong rationale for prevention of renal disease through the more effective
control of GAS
skin infections in childhood and through the prevention of obesity in adult
life.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age distribution</subject><subject>Albuminuria</subject><subject>Albuminuria - immunology</subject><subject>Albuminuria - microbiology</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial</subject><subject>Bacterial diseases</subject><subject>Bacterial Outer Membrane Proteins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>Child</subject><subject>Childhood</subject><subject>Connectin</subject><subject>Cross-Sectional Studies</subject><subject>Diabetic nephropathies</subject><subject>Endemic Diseases - statistics & numerical data</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glomerulonephritis</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Kidney Failure, Chronic - microbiology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Muscle Proteins</subject><subject>Myeloma Proteins</subject><subject>Northern Territory</subject><subject>Obesity - complications</subject><subject>Overweight</subject><subject>Prospective Studies</subject><subject>Proteinuria</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcal Infections - complications</subject><subject>Streptococcus</subject><subject>Streptococcus pyogenes - immunology</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkV1rFDEUhoModlv9AYJILsS70WQy-boR1qJVXL-oXockk9lmOzuZJplq_71ZZ1krgkIgIe9zXs45LwCPMHqOEeYvzpGkqGZCSIEQFri-Axa4YbJqGiTvgsVOrnb6EThOaYMQkrXg98ERLi_BBV-Ay88xZOeHKXoNfYI6pWC9zq6F332-gKOLyafsButg6KAesjehvYE5wJSjG3OwwVrdww9wnJ1gOUsTol_7ofwvp8Lp3ushPQD3Ot0n93B_n4Bvb15_PX1brT6dvTtdripLMc0Vr7mghLlWI24wNQSbhhHcWYY74oSTrmm4NYQQTlsrBKasxtpYTrAWDTHkBLycfcfJbF1r3bDrQI3Rb3W8UUF79acy-Au1DteqFmVjQhaDZ3uDGK4ml7La-mRd3-vBhSkpJhklCNf_BTGvqZSSFBDPoI0hpei6QzcYqV2W6q8sS82T22PcqpjDK8DTPaBTiaCLerA-_eY4luQX9njGNimHeJCJYLQmrMjVLO9i_nGQdbxUjJcVK3b2Ra3OCXn18T1TTeHJfhS9NdG3a6c2YYol6_SPYX4CD5jQTA</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>GOODFELLOW, A. M.</creator><creator>HOY, W. E.</creator><creator>SRIPRAKASH, K. S.</creator><creator>DALY, M. J.</creator><creator>REEVE, M. P.</creator><creator>MATHEWS, J. D.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990201</creationdate><title>Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians</title><author>GOODFELLOW, A. M. ; HOY, W. E. ; SRIPRAKASH, K. S. ; DALY, M. J. ; REEVE, M. P. ; MATHEWS, J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-7278536eda07b15b31b4631fc61f3e8e9e447cb33375dc8815621abc731a843b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age distribution</topic><topic>Albuminuria</topic><topic>Albuminuria - immunology</topic><topic>Albuminuria - microbiology</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens, Bacterial</topic><topic>Bacterial diseases</topic><topic>Bacterial Outer Membrane Proteins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>Child</topic><topic>Childhood</topic><topic>Connectin</topic><topic>Cross-Sectional Studies</topic><topic>Diabetic nephropathies</topic><topic>Endemic Diseases - statistics & numerical data</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glomerulonephritis</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Kidney Failure, Chronic - microbiology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Muscle Proteins</topic><topic>Myeloma Proteins</topic><topic>Northern Territory</topic><topic>Obesity - complications</topic><topic>Overweight</topic><topic>Prospective Studies</topic><topic>Proteinuria</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcal Infections - complications</topic><topic>Streptococcus</topic><topic>Streptococcus pyogenes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOODFELLOW, A. M.</creatorcontrib><creatorcontrib>HOY, W. E.</creatorcontrib><creatorcontrib>SRIPRAKASH, K. S.</creatorcontrib><creatorcontrib>DALY, M. J.</creatorcontrib><creatorcontrib>REEVE, M. P.</creatorcontrib><creatorcontrib>MATHEWS, J. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOODFELLOW, A. M.</au><au>HOY, W. E.</au><au>SRIPRAKASH, K. S.</au><au>DALY, M. J.</au><au>REEVE, M. P.</au><au>MATHEWS, J. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>122</volume><issue>1</issue><spage>67</spage><epage>75</epage><pages>67-75</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>Aboriginal communities in Northern Australia with high rates of
group A streptococcal (GAS)
skin infection in childhood also have high rates of renal failure in adult
life. In a cross-sectional study of one such high risk community, albuminuria was used as
a marker of renal
disease. The prevalence of albuminuria increased from 0/52 in subjects
aged 10–19 years to
10/29 (32·9%) in those aged 50 or more (P<0·001).
Antibodies to streptococcal M protein,
markers of past GAS infection, were present in 48/52 (92%) at ages
10–19 years, 16/32 (50%)
at ages 30–39, and 20/29 (69%) in those aged 50 or more. After
allowing for the age-dependencies of albuminuria and of M protein antibodies (P<0·001)
albuminuria was
significantly associated with M protein antibodies (P<0·01).
Thus, 72% of adults aged 30 or
more with M protein antibodies also had albuminuria, compared with only
21% of those who
were seronegative. More detailed modelling suggested that although most
Aboriginal people in
this community developed M protein antibodies following GAS infection in
childhood, the
development of proteinuria was associated with the persistence of such
seropositivity into adult
life. The models predicted that proteinuria developed at a mean age of
30 years in seropositive
persons, at 45 years in seronegative persons who were overweight, and at
62 years in
seronegative persons of normal weight. We demonstrated a clear association
between evidence
of childhood GAS infection and individual risk of proteinuria in adult
life. This study provided
a strong rationale for prevention of renal disease through the more effective
control of GAS
skin infections in childhood and through the prevention of obesity in adult
life.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10098787</pmid><doi>10.1017/S0950268898001812</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 1999-02, Vol.122 (1), p.67-75 |
| issn | 0950-2688 1469-4409 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2809589 |
| source | JSTOR Archival Journals and Primary Sources Collection; Cambridge University Press; PubMed Central |
| subjects | Adolescent Adult Age distribution Albuminuria Albuminuria - immunology Albuminuria - microbiology Antibodies Antibodies, Bacterial - blood Antigens, Bacterial Bacterial diseases Bacterial Outer Membrane Proteins Bacteriology Biological and medical sciences Carrier Proteins Child Childhood Connectin Cross-Sectional Studies Diabetic nephropathies Endemic Diseases - statistics & numerical data Epidemiology Fundamental and applied biological sciences. Psychology Glomerulonephritis Human bacterial diseases Humans Infections Infectious diseases Kidney Failure, Chronic - microbiology Medical sciences Microbiology Middle Aged Muscle Proteins Myeloma Proteins Northern Territory Obesity - complications Overweight Prospective Studies Proteinuria Regression Analysis Risk Factors Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcal Infections - complications Streptococcus Streptococcus pyogenes - immunology |
| title | Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians |
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