Mammographic Features and Histopathological Findings of Interval Breast Cancers

Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease. Purpose: To describe the mammographic features and prognostic...

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Bibliographic Details
Published in:Acta radiologica (1987) 2008-11, Vol.49 (9), p.975-981
Main Authors: Hofvind, S., Geller, B., Skaane, P.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
False Negative Reactions
Female
Genital system. Mammary gland
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lymph Nodes - diagnostic imaging
Mammary gland diseases
Mammography
Mass Screening
Medical sciences
Middle Aged
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Retrospective Studies
Time Factors
Tumors
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Summary:Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease. Purpose: To describe the mammographic features and prognostic histopathological tumor characteristics of interval breast cancers. Material and Methods: A total of 231 interval breast cancer cases diagnosed in prevalently screened women aged 50-69 years old were examined. Thirty-five percent of the cases were retrospectively classified as missed cancers, 23% as minimal sign, and 42% as true negative (including occult cancers) in a definitive classification performed by six experienced breast radiologists. The retrospective classification described the mammographic features of the baseline screening mammograms in missed and minimal-sign interval cancers, while histopathological reports were used to describe the tumor characteristics in all the subgroups of interval cancers. Results: Fifty percent of the missed and minimal-sign interval cancers combined presented poorly defined mass or asymmetric density, and 26% calcifications with or without associated density or mass at baseline screening. Twenty-seven percent of invasive tumors were
ISSN:0284-1851
1600-0455
DOI:10.1080/02841850802403730