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Mammographic Features and Histopathological Findings of Interval Breast Cancers
Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease. Purpose: To describe the mammographic features and prognostic...
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| Published in: | Acta radiologica (1987) 2008-11, Vol.49 (9), p.975-981 |
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| container_issue | 9 |
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| container_title | Acta radiologica (1987) |
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| creator | Hofvind, S. Geller, B. Skaane, P. |
| description | Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease.
Purpose: To describe the mammographic features and prognostic histopathological tumor characteristics of interval breast cancers.
Material and Methods: A total of 231 interval breast cancer cases diagnosed in prevalently screened women aged 50-69 years old were examined. Thirty-five percent of the cases were retrospectively classified as missed cancers, 23% as minimal sign, and 42% as true negative (including occult cancers) in a definitive classification performed by six experienced breast radiologists. The retrospective classification described the mammographic features of the baseline screening mammograms in missed and minimal-sign interval cancers, while histopathological reports were used to describe the tumor characteristics in all the subgroups of interval cancers.
Results: Fifty percent of the missed and minimal-sign interval cancers combined presented poorly defined mass or asymmetric density, and 26% calcifications with or without associated density or mass at baseline screening. Twenty-seven percent of invasive tumors were |
| doi_str_mv | 10.1080/02841850802403730 |
| format | article |
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Purpose: To describe the mammographic features and prognostic histopathological tumor characteristics of interval breast cancers.
Material and Methods: A total of 231 interval breast cancer cases diagnosed in prevalently screened women aged 50-69 years old were examined. Thirty-five percent of the cases were retrospectively classified as missed cancers, 23% as minimal sign, and 42% as true negative (including occult cancers) in a definitive classification performed by six experienced breast radiologists. The retrospective classification described the mammographic features of the baseline screening mammograms in missed and minimal-sign interval cancers, while histopathological reports were used to describe the tumor characteristics in all the subgroups of interval cancers.
Results: Fifty percent of the missed and minimal-sign interval cancers combined presented poorly defined mass or asymmetric density, and 26% calcifications with or without associated density or mass at baseline screening. Twenty-seven percent of invasive tumors were <15 mm for missed and 47% for true interval cancers (P<0.001). Lymph node involvement was more common in missed (49%) compared with the true cases (33%, P<0.05).
Conclusion: Missed interval cancers have less prognostically favorable histopathological tumor characteristics compared with true interval cancers. Improving the radiologist's perception and interpretation by establishing systematic collection of features and implementation of organized reviews may decrease the number of interval cancers in a screening program.</description><identifier>ISSN: 0284-1851</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1080/02841850802403730</identifier><identifier>PMID: 18785026</identifier><identifier>CODEN: ACRAE3</identifier><language>eng</language><publisher>London, England: Informa UK Ltd</publisher><subject>Aged ; Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; False Negative Reactions ; Female ; Genital system. Mammary gland ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymph Nodes - diagnostic imaging ; Mammary gland diseases ; Mammography ; Mass Screening ; Medical sciences ; Middle Aged ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Retrospective Studies ; Time Factors ; Tumors</subject><ispartof>Acta radiologica (1987), 2008-11, Vol.49 (9), p.975-981</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-2ecaf05c450bd2f5ecc79efaf628da6c61a42b395767fab4c8c1dabacefdcaf03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924,79135</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20845860$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18785026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofvind, S.</creatorcontrib><creatorcontrib>Geller, B.</creatorcontrib><creatorcontrib>Skaane, P.</creatorcontrib><title>Mammographic Features and Histopathological Findings of Interval Breast Cancers</title><title>Acta radiologica (1987)</title><addtitle>Acta Radiol</addtitle><description>Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease.
Purpose: To describe the mammographic features and prognostic histopathological tumor characteristics of interval breast cancers.
Material and Methods: A total of 231 interval breast cancer cases diagnosed in prevalently screened women aged 50-69 years old were examined. Thirty-five percent of the cases were retrospectively classified as missed cancers, 23% as minimal sign, and 42% as true negative (including occult cancers) in a definitive classification performed by six experienced breast radiologists. The retrospective classification described the mammographic features of the baseline screening mammograms in missed and minimal-sign interval cancers, while histopathological reports were used to describe the tumor characteristics in all the subgroups of interval cancers.
Results: Fifty percent of the missed and minimal-sign interval cancers combined presented poorly defined mass or asymmetric density, and 26% calcifications with or without associated density or mass at baseline screening. Twenty-seven percent of invasive tumors were <15 mm for missed and 47% for true interval cancers (P<0.001). Lymph node involvement was more common in missed (49%) compared with the true cases (33%, P<0.05).
Conclusion: Missed interval cancers have less prognostically favorable histopathological tumor characteristics compared with true interval cancers. Improving the radiologist's perception and interpretation by establishing systematic collection of features and implementation of organized reviews may decrease the number of interval cancers in a screening program.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>False Negative Reactions</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Mammary gland diseases</subject><subject>Mammography</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0284-1851</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhS0EokvhB3BBudBbiu2NHa-QkOiqSyu16qWcrYkzTlwl9mInlfj3dbSrAkJCnGx53vdm_IaQ94yeM6roJ8pVxZTIV17Rdb2mL8iKSUpLWgnxkqyWepkF7IS8SemBUsZrwV6TE6bqjHG5Ine3MI6hi7DvnSl2CNMcMRXg2-LKpSnsYerDEDpnYCh2zrfOd6kItrj2E8bH_HgREdJUbMEbjOkteWVhSPjueJ6S77vL--1VeXP37Xr79aY0gqmp5GjAUmEqQZuWW4HG1Bu0YCVXLUgjGVS8WW9ELWsLTWWUYS00YNC2C7k-JV8Ovvu5GbE16KcIg95HN0L8qQM4_WfFu1534VFzlT_PN9ng7GgQw48Z06RHlwwOA3gMc9JyI-tK0aUTOwhNDClFtM9NGNXLGvRfa8jMh9-n-0Ucc8-Cj0cBpJysjTk9l551nKpKKLkYnR90CTrUD2GOPqf6z86fD4DzNsQReoRh6g3E_6KfAIbpsm0</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Hofvind, S.</creator><creator>Geller, B.</creator><creator>Skaane, P.</creator><general>Informa UK Ltd</general><general>SAGE Publications</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200811</creationdate><title>Mammographic Features and Histopathological Findings of Interval Breast Cancers</title><author>Hofvind, S. ; Geller, B. ; Skaane, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-2ecaf05c450bd2f5ecc79efaf628da6c61a42b395767fab4c8c1dabacefdcaf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>False Negative Reactions</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Mammary gland diseases</topic><topic>Mammography</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hofvind, S.</creatorcontrib><creatorcontrib>Geller, B.</creatorcontrib><creatorcontrib>Skaane, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta radiologica (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofvind, S.</au><au>Geller, B.</au><au>Skaane, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammographic Features and Histopathological Findings of Interval Breast Cancers</atitle><jtitle>Acta radiologica (1987)</jtitle><addtitle>Acta Radiol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>49</volume><issue>9</issue><spage>975</spage><epage>981</epage><pages>975-981</pages><issn>0284-1851</issn><eissn>1600-0455</eissn><coden>ACRAE3</coden><abstract>Background: Interval cancers are considered a shortcoming in screening mammography due to less favorable prognostic tumor characteristics compared to screening-detected cancers and consequently a lower chance of survival from the disease.
Purpose: To describe the mammographic features and prognostic histopathological tumor characteristics of interval breast cancers.
Material and Methods: A total of 231 interval breast cancer cases diagnosed in prevalently screened women aged 50-69 years old were examined. Thirty-five percent of the cases were retrospectively classified as missed cancers, 23% as minimal sign, and 42% as true negative (including occult cancers) in a definitive classification performed by six experienced breast radiologists. The retrospective classification described the mammographic features of the baseline screening mammograms in missed and minimal-sign interval cancers, while histopathological reports were used to describe the tumor characteristics in all the subgroups of interval cancers.
Results: Fifty percent of the missed and minimal-sign interval cancers combined presented poorly defined mass or asymmetric density, and 26% calcifications with or without associated density or mass at baseline screening. Twenty-seven percent of invasive tumors were <15 mm for missed and 47% for true interval cancers (P<0.001). Lymph node involvement was more common in missed (49%) compared with the true cases (33%, P<0.05).
Conclusion: Missed interval cancers have less prognostically favorable histopathological tumor characteristics compared with true interval cancers. Improving the radiologist's perception and interpretation by establishing systematic collection of features and implementation of organized reviews may decrease the number of interval cancers in a screening program.</abstract><cop>London, England</cop><pub>Informa UK Ltd</pub><pmid>18785026</pmid><doi>10.1080/02841850802403730</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta radiologica (1987), 2008-11, Vol.49 (9), p.975-981 |
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| language | eng |
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| source | SAGE |
| subjects | Aged Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology False Negative Reactions Female Genital system. Mammary gland Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Lymph Nodes - diagnostic imaging Mammary gland diseases Mammography Mass Screening Medical sciences Middle Aged Radiodiagnosis. Nmr imagery. Nmr spectrometry Retrospective Studies Time Factors Tumors |
| title | Mammographic Features and Histopathological Findings of Interval Breast Cancers |
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