Failure of a Glass Ionomer to Remineralize Apatite-depleted Dentin

Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free...

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Bibliographic Details
Published in:Journal of dental research 2010-03, Vol.89 (3), p.230-235
Main Authors: Kim, Y.K., Yiu, C.K.Y., Kim, J.R., Gu, L., Kim, S.K., Weller, R.N., Pashley, D.H., Tay, F.R.
Format: Article
Language:English
Subjects:
Acids
Aluminum
Apatite
Apatites - administration & dosage
Apatites - chemistry
Calcium phosphates
Cement
Collagen
Crystals
Dental Restoration Failure
Dental Restoration, Permanent - methods
Dentin
Dentin - drug effects
Dentistry
Fluorine
Glass Ionomer Cements - chemistry
Glass Ionomer Cements - therapeutic use
Humans
Nanocrystals
Phosphorus
Remineralization
Research Reports
Strontium
Tooth Demineralization - therapy
Tooth Remineralization - methods
Transmission electron microscopy
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Summary:Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IXGP, and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1–4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034509357172