The effect of l-arginine and creatine on vascular function and homocysteine metabolism

Abstract Studies with l-arginine supplementation have shown inconsistent effects on endothelial function. The generation of guanidinoacetate (GAA) from l-arginine with subsequent formation of creatine and homocysteine and consumption of methionine may reduce the pool of l-arginine available for nitr...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2009-08, Vol.14 (3), p.239-248
Main Authors: Jahangir, Eiman, Vita, Joseph A, Handy, Diane, Holbrook, Monica, Palmisano, Joseph, Beal, Ryan, Loscalzo, Joseph, Eberhardt, Robert T
Format: Article
Language:English
Subjects:
Aged
Arginine - blood
Arginine - therapeutic use
Biological and medical sciences
Blood and lymphatic vessels
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiopathology
Cardiology. Vascular system
Coronary Artery Disease - drug therapy
Coronary Artery Disease - metabolism
Coronary Artery Disease - physiopathology
Coronary heart disease
Creatine - blood
Creatine - therapeutic use
Dietary Supplements
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Glycine - analogs & derivatives
Glycine - blood
Heart
Homocysteine - blood
Humans
Hyperemia - physiopathology
Male
Medical sciences
Methionine - blood
Middle Aged
Regional Blood Flow
Treatment Outcome
Ultrasonography
Vasodilation - drug effects
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Summary:Abstract Studies with l-arginine supplementation have shown inconsistent effects on endothelial function. The generation of guanidinoacetate (GAA) from l-arginine with subsequent formation of creatine and homocysteine and consumption of methionine may reduce the pool of l-arginine available for nitric oxide generation. Experimental studies suggest that creatine supplementation might block this pathway. We sought to determine the effects of l-arginine, creatine, or the combination on endothelium-dependent vasodilation and homocysteine metabolism in patients with coronary artery disease. Patients with coronary artery disease were randomized to l-arginine (9 g/day), creatine (21 g/day), l-arginine plus creatine, or placebo for 4 days (n = 26–29/group). Brachial artery flow-mediated dilation and plasma levels of l-arginine, creatine, homocysteine, methionine, and GAA were measured at baseline and follow-up. l-Arginine and creatine supplementation had no effects on vascular function. l-Arginine alone increased GAA (p 
ISSN:1358-863X
1477-0377
DOI:10.1177/1358863X08100834