Shape Differences in the Corpus Callosum in First-Episode Schizophrenia and First-Episode Psychotic Affective Disorder

OBJECTIVE: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore...

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Bibliographic Details
Published in:The American journal of psychiatry 2002-05, Vol.159 (5), p.866-868
Main Authors: Frumin, Melissa, Golland, Polina, Kikinis, Ron, Hirayasu, Yoshio, Salisbury, Dean F., Hennen, John, Dickey, Chandlee C., Anderson, Mark, Jolesz, Ferenc A., Grimson, W. Eric L., McCarley, Robert W., Shenton, Martha E.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective Disorders, Psychotic - diagnosis
Artificial Intelligence
Biological and medical sciences
Brain
Corpus Callosum - anatomy & histology
Diagnosis, Differential
Female
Humans
Image Processing, Computer-Assisted - statistics & numerical data
Magnetic Resonance Imaging - statistics & numerical data
Male
Medical sciences
Neurology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
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Summary:OBJECTIVE: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality. METHOD: Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects. RESULTS: No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder. CONCLUSIONS: Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.159.5.866