Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder

Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood....

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Published in:Journal of the International Neuropsychological Society 2009-05, Vol.15 (3), p.476-481
Main Authors: KALMAR, JESSICA H., WANG, FEI, SPENCER, LINDA, EDMISTON, ERIN, LACADIE, CHERYL M., MARTIN, ANDRÉS, CONSTABLE, R. TODD, DUNCAN, JAMES S., STAIB, LAWRENCE H., PAPADEMETRIS, XENOPHON, BLUMBERG, HILARY P.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Bipolar disorder
Bipolar Disorder - pathology
Brain Mapping
Development
Developmental Disabilities - pathology
Disease Progression
Female
Follow-Up Studies
Humans
Longitudinal
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Neuropsychological Tests
Prefrontal cortex
Prefrontal Cortex - abnormalities
Psychotropic drugs
Teenagers
Time Factors
Young Adult
Young adults
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Summary:Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BD I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostral anterior cingulate cortex (p < .05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD. (JINS, 2009, 15, 476–481.)
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617709090584