Exposures to Particulate Matter and Polycyclic Aromatic Hydrocarbons and Oxidative Stress in Schoolchildren

• Published in: Environmental health perspectives 2010-04, Vol.118 (4), p.579-583
• Main Authors: Bae, Sanghyuk, Pan, Xiao-Chuan, Kim, Su-Young, Park, Kwangsik, Kim, Yoon-Hee, Kim, Ho, Hong, Yun-Chul
• Format: Article
• Language: English
• Subjects: Air; Air Pollutants - adverse effects; Air pollution; Asthma; Biological and medical sciences; Biological markers; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; Chemical and industrial products toxicology. Toxic occupational diseases; Chemical hazards; Child; Children; Children's Health; Elementary school students; Environment. Living conditions; Environmental pollutants toxicology; Female; Health aspects; Heating fuels; Humans; Male; Malondialdehyde - urine; Medical sciences; Metals and various inorganic compounds; Oxidative stress; Oxidative Stress - drug effects; Particles; Particulate matter; Particulate Matter - toxicity; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - toxicity; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk factors; Toxicology; Tumors; Urine
• ISSN: 0091-6765; 1552-9924
• DOI: 10.1289/ehp.0901077

Background: Air pollution is known to contribute to respiratory and cardiovascular mortality and morbidity. Oxidative stress has been suggested as one of the main mechanisms for these effects on health. Objective: The aim of this study was to analyze the effects of exposure to particulate matter (PM) with aerodynamic diameters ≤ 10 μm (PM₁₀) and ≤ 2.5 μm (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) on urinary malondialdehyde (MDA) levels in schoolchildren. Methods: The study population consisted of 120 schoolchildren. The survey and measurements were conducted in four cities—two in China (Ala Shan and Beijing) and two in Korea (Jeju and Seoul)—between 4 and 9 June 2007. We measured daily ambient levels of PM and their metal components at the selected schools during the study period. We also measured urinary 1-hydroxypyrene (1-OHP) and 2-naphthol, to assess PAH exposure, and MDA, to assess oxidative stress. Measurements were conducted once a day for 5 consecutive days. We constructed a linear mixed model after adjusting for individual variables to estimate the effects of PM and PAH on oxidative stress. Results: We found statistically significant increases in urinary MDA levels with ambient PM concentrations from the current day to the 2 previous days (p < 0.0001). Urinary 1-OHP level also showed a positive association with urinary MDA level, which was statistically significant with or without PM in the model (p < 0.05). Outdoor PM and urinary 1-OHP were synergistically associated with urinary MDA levels. Some metals bound to PM₁₀ (aluminum, iron, strontium, magnesium, silicon, arsenic, barium, zinc, copper, and cadmium) and PM2.5 (magnesium, iron, strontium, arsenic, cadmium, zinc, aluminum, mercury, barium, and copper) also had significant associations with urinary MDA level. Conclusion: Exposure to PM air pollution and PAHs was associated with oxidative stress in schoolchildren.