Extent and magnitude of catecholamine surge in pediatric burned patients

Increased catecholamine (CA) levels after severe burn are associated with stress, inflammation, hypermetabolism, and impaired immune function. The CA secretion profiles in burned patients are not well described. Mechanisms, duration, and extent of CA surge are unknown. The purpose of this large unic...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2010-04, Vol.33 (4), p.369-374
Main Authors: Kulp, Gabriela A, Herndon, David N, Lee, Jong O, Suman, Oscar E, Jeschke, Marc G
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Burns - pathology
Burns - physiopathology
Burns - urine
Catecholamines - urine
Child
Child, Preschool
Cytokines - urine
Dopamine - urine
Epinephrine - urine
Female
Granulocyte Colony-Stimulating Factor - urine
Heart Rate
Humans
Inflammation - physiopathology
Inflammation - urine
Interleukin-6 - urine
Interleukin-8 - urine
Male
Norepinephrine - urine
Sex Factors
Tumor Necrosis Factor-alpha - urine
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Summary:Increased catecholamine (CA) levels after severe burn are associated with stress, inflammation, hypermetabolism, and impaired immune function. The CA secretion profiles in burned patients are not well described. Mechanisms, duration, and extent of CA surge are unknown. The purpose of this large unicenter study was to evaluate the extent and magnitude of CA surge after severe burn in pediatric patients. Patients admitted between 1996 and 2008 were enrolled in this study. Twenty-four-hour urine collections were performed during acute hospitalization and up to 2 years postburn. Results from the samples collected from 12 normal, healthy volunteers were compared with the data from the burned patients. Relevant demographic and clinical information was obtained from medical records. Student t-test and one-way ANOVA were used to analyze the data where appropriate. Significance was accepted at P < 0.05. Four hundred thirteen patients were enrolled in this study; 17 patients died during acute hospitalization. Burn caused a marked stress and inflammatory response, indicated by massive tachycardia and elevated proinflammatory cytokines. In burned patients, CA levels are consistently and significantly modulated after burn when compared with the levels in normal, healthy volunteers. Catecholamine levels were significantly higher in boys compared with girls, correlated with burn size in burns greater than 40%, and were increased in older children. There were differences over time in survivors versus nonsurvivors, with CA levels significantly higher in nonsurvivors at two time points. Inflammatory cytokines show a similar profile during the study period. Our study gives clinicians a useful insight into the extent and magnitude of CA elevation to better design treatment strategies.
ISSN:1073-2322
1540-0514
DOI:10.1097/SHK.0b013e3181b92340