Isoprenaline increases the slopes of restitution trajectory in the conscious rabbit with ischemic heart failure

Roughly speaking, restitution is the dependence of recovery time of cardiac electrical activity on heart rate. Increased restitution slope is theorized to be predictive of sudden death after heart injury such as from coronary artery occlusion (ischemia). Adrenaline analogs are known to increase rest...

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Bibliographic Details
Published in:Journal of biological physics 2010-06, Vol.36 (3), p.299-315
Main Authors: Kimotsuki, Tomofumi, Niwa, Noriko, Hicks, Martin N, Dunne, Michael, Cobbe, Stuart M, Watanabe, Mari Alford
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biophysics
Complex Fluids and Microfluidics
Complex Systems
Electrocardiography
Heart failure
Neurosciences
Original Paper
Pharmacology
Physics
Physics and Astronomy
Psychotropic drugs
QT dynamicity
Rabbits
Repolarization dynamics
Restitution
Soft and Granular Matter
Sudden cardiac death
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Summary:Roughly speaking, restitution is the dependence of recovery time of cardiac electrical activity on heart rate. Increased restitution slope is theorized to be predictive of sudden death after heart injury such as from coronary artery occlusion (ischemia). Adrenaline analogs are known to increase restitution slope in normal hearts, but their effects in failing hearts are unknown. Twenty-six rabbits underwent coronary ligation (n = 15) or sham surgery (n = 11) and implantation of a lead in the heart for recording electrocardiograms. Eight weeks later, unanesthetized rabbits were given 0.25-2.0 ml of 1 μmol/L isoprenaline intravenously, which increased heart rate. Heart rate was quantified by time between QRS peaks (RR) and heart activity duration by R to T peak time (QTp). Ligated rabbits (n = 6) had lower ejection fraction than sham rabbits (n = 7, p 1 in ligated rabbits (1.27 ± 0.66) and
ISSN:0092-0606
1573-0689
DOI:10.1007/s10867-009-9185-5