The effect of different anesthetics on neurovascular coupling

To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurova...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-07, Vol.51 (4), p.1367-1377
Main Authors: Franceschini, Maria Angela, Radhakrishnan, Harsha, Thakur, Kiran, Wu, Weicheng, Ruvinskaya, Svetlana, Carp, Stefan, Boas, David A.
Format: Article
Language:English
Subjects:
Anesthetics - pharmacology
Animals
Blood Vessels - drug effects
Blood Vessels - innervation
Brain
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Cerebrovascular Circulation - drug effects
Electric Stimulation
Electroencephalography
Evoked Potentials, Somatosensory - drug effects
Forelimb - physiology
Heart rate
Hemoglobins - metabolism
Hypercapnia - physiopathology
Image Processing, Computer-Assisted
Male
Metabolism
Neurons - physiology
Rats
Rats, Sprague-Dawley
Rodents
Studies
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Thalamus - drug effects
Thalamus - physiology
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Summary:To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurovascular coupling. Simultaneous scalp electroencephalography (EEG) and diffuse optical imaging (DOI) measurements were obtained during multiple conditions of event-related electrical forepaw stimulation in 33 male Sprague–Dawley rats divided into 6 groups depending on the maintaining anesthetic — alpha-chloralose, pentobarbital, ketamine–xylazine, fentanyl–droperidol, isoflurane, or propofol. The somatosensory evoked potentials (SEP) were decomposed into four components and the question of which best predicts the hemodynamic responses was investigated. Results of the linear regression analysis show that the hemodynamic response is best correlated with the secondary and late cortico-cortical transmissions and not with the initial thalamic input activity in layer IV. Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.03.060