The effect of different anesthetics on neurovascular coupling

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2010-07, Vol.51 (4), p.1367-1377
• Main Authors: Franceschini, Maria Angela, Radhakrishnan, Harsha, Thakur, Kiran, Wu, Weicheng, Ruvinskaya, Svetlana, Carp, Stefan, Boas, David A.
• Format: Article
• Language: English
• Subjects: Anesthetics - pharmacology; Animals; Blood Vessels - drug effects; Blood Vessels - innervation; Brain; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Cerebrovascular Circulation - drug effects; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory - drug effects; Forelimb - physiology; Heart rate; Hemoglobins - metabolism; Hypercapnia - physiopathology; Image Processing, Computer-Assisted; Male; Metabolism; Neurons - physiology; Rats; Rats, Sprague-Dawley; Rodents; Studies; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Thalamus - drug effects; Thalamus - physiology
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2010.03.060

To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurovascular coupling. Simultaneous scalp electroencephalography (EEG) and diffuse optical imaging (DOI) measurements were obtained during multiple conditions of event-related electrical forepaw stimulation in 33 male Sprague–Dawley rats divided into 6 groups depending on the maintaining anesthetic — alpha-chloralose, pentobarbital, ketamine–xylazine, fentanyl–droperidol, isoflurane, or propofol. The somatosensory evoked potentials (SEP) were decomposed into four components and the question of which best predicts the hemodynamic responses was investigated. Results of the linear regression analysis show that the hemodynamic response is best correlated with the secondary and late cortico-cortical transmissions and not with the initial thalamic input activity in layer IV. Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used.