CD8+ Tregs in lupus, autoimmunity, and beyond

Abstract While CD4+ CD25high regulatory T cells (Tregs) have garnered much attention for their role in the maintenance of immune homeostasis, recent findings have shown that subsets of CD8+ T cells (CD8+ Tregs) display immunoregulatory functions as well. Both CD4+ Tregs and CD8+ Tregs appear impaire...

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Bibliographic Details
Published in:Autoimmunity reviews 2010-06, Vol.9 (8), p.560-568
Main Authors: Dinesh, Ravi K, Skaggs, Brian J, La Cava, Antonio, Hahn, Bevra H, Singh, Ram Pyare
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoimmunity
CD8 + Tregs
Immune tolerance/suppression
Systemic lupus erythematosus
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Summary:Abstract While CD4+ CD25high regulatory T cells (Tregs) have garnered much attention for their role in the maintenance of immune homeostasis, recent findings have shown that subsets of CD8+ T cells (CD8+ Tregs) display immunoregulatory functions as well. Both CD4+ Tregs and CD8+ Tregs appear impaired in number and/or function in several autoimmune diseases and in experimental animal models of autoimmunity, suggesting the possibility of immunotherapeutic targeting of these cells for improved management of autoimmune conditions. Our group has developed a strategy to induce CD8+ Tregs in autoimmune mice through the use of a tolerogenic self-peptide, and new information has been gained on the phenotype, function and role of induced CD8+ Tregs in autoimmunity. Here we present an overview of the role and mechanisms of action of CD8+ Tregs in autoimmunity, with a special focus on lupus. We also discuss the potential role of CD8+ Tregs in other diseases, including chronic infection and cancer.
ISSN:1568-9972
1568-9972
1873-0183
DOI:10.1016/j.autrev.2010.03.006