Staphylococcus aureus extracellular adherence protein contributes to biofilm formation in the presence of serum

Staphylococcus aureus extracellular adherence protein (EAP) is secreted, but it can redock on the bacterial cell surface via neutral phosphatase (Nptase). EAP binds to certain blood proteins and to itself, and through these affinities, it contributes to adherence and aggregation. It has been demonst...

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Bibliographic Details
Published in:FEMS microbiology letters 2010-04, Vol.305 (2), p.143-147
Main Authors: Thompson, Karl M, Abraham, Nabil, Jefferson, Kimberly K
Format: Article
Language:English
Subjects:
Bacterial Adhesion
Bacterial Proteins - metabolism
Bacteriology
biofilm
Biofilms
Biofilms - growth & development
Biological and medical sciences
Cell surface
EAP
Fundamental and applied biological sciences. Psychology
Humans
Iron
Iron - metabolism
Microbiology
Miscellaneous
Pathogens
Phosphoric Monoester Hydrolases - metabolism
Protein Binding
Proteins
RNA-Binding Proteins - metabolism
Serum - microbiology
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - growth & development
Staphylococcus aureus - physiology
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Summary:Staphylococcus aureus extracellular adherence protein (EAP) is secreted, but it can redock on the bacterial cell surface via neutral phosphatase (Nptase). EAP binds to certain blood proteins and to itself, and through these affinities, it contributes to adherence and aggregation. It has been demonstrated previously that EAP expression is iron regulated and it contributes to biofilm formation under iron-deplete conditions. In this study, we found that EAP and Nptase also play a role in biofilm formation under iron-replete conditions in the presence of human serum.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2010.01918.x