Neoplasia in the chimpanzee (Pan spp.)

Background  Chimpanzees have over 98% genomic sequence homology with humans and may have a similar host response to malignancy. There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research. Methods  Spon...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical primatology 2009-04, Vol.38 (2), p.137-144
Main Authors: Brown, S.L., Anderson, D.C., Dick Jr, E.J., Guardado-Mendoza, R., Garcia, A.P., Hubbard, G.B.
Format: Article
Language:English
Subjects:
Animals
Ape
Ape Diseases - diagnosis
cancer
disease
Female
leiomyoma
Leiomyoma - diagnosis
Male
Neoplasms - diagnosis
Neoplasms - veterinary
non-human primate
Pan troglodytes
tumor
Uterine Neoplasms - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background  Chimpanzees have over 98% genomic sequence homology with humans and may have a similar host response to malignancy. There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research. Methods  Spontaneous neoplasia that was documented in two chimpanzee colonies and in the literature were evaluated statistically. Results  In all, 105 spontaneous and 12 experimental neoplasms were diagnosed. Seventy‐four spontaneous tumors occurred in females, 24 in males, and seven in animals of undetermined sex. Of the spontaneous tumors 89 were benign, 14 were malignant, and two were undetermined. Neoplasia was most common in the urogenital system in females. Conclusions  Neoplasia is not uncommon in the chimpanzee, is generally benign, and occurs primarily in the urogenital system in females.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.2008.00321.x