Long-Term Risk of Atrial Fibrillation With Symptomatic Gastroesophageal Reflux Disease and Esophagitis

The mechanisms underlying the triggers and maintenance of atrial fibrillation (AF) are not fully understood. One potential unproved mechanism is that gastroesophageal reflux disease (GERD), in which acid reflux induces local and systemic inflammation, may increase triggered activity in the myocardiu...

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Bibliographic Details
Published in:The American journal of cardiology 2008-11, Vol.102 (9), p.1207-1211
Main Authors: Bunch, T. Jared, MD, Packer, Douglas L., MD, Jahangir, Arshad, MD, Locke, G. Richard, MD, Talley, Nicholas J., MD, PhD, Gersh, Bernard J., MBChB, DPhil, Roy, Ranjini R., MD, Hodge, David O., MS, Asirvatham, Samuel J., MD
Format: Article
Language:English
Subjects:
Adult
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - etiology
Biological and medical sciences
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular system
Electrocardiography
Esophagitis - complications
Esophagus
Female
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal reflux
Gastroesophageal Reflux - complications
Health risk assessment
Heart
Humans
Hydrogen-Ion Concentration
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Risk Factors
Surveys and Questionnaires
Time Factors
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Summary:The mechanisms underlying the triggers and maintenance of atrial fibrillation (AF) are not fully understood. One potential unproved mechanism is that gastroesophageal reflux disease (GERD), in which acid reflux induces local and systemic inflammation, may increase triggered activity in the myocardium and pulmonary veins and increase AF risk. A self-report questionnaire was mailed to a random sample of 5,288 residents of Olmsted County, Minnesota, aged 25 to 74 years to assess the presence and frequency of GERD from 1988 to 1994. The long-term risk for AF over a period of 11.4 ± 5.0 years was determined through review of clinical evaluations and the electrocardiographic database in those without previous AF. The average age was 53 ± 17 years, and 2,571 subjects (49%) were man. Of these patients, 741 developed AF (cumulative probability of AF at 18 years 20%, 95% confidence interval [CI] 17% to 22%). Age (hazard ratio [HR] 1.09, 95% CI 1.08 to 1.10, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2008.06.048