TransFind--predicting transcriptional regulators for gene sets

The analysis of putative transcription factor binding sites in promoter regions of coregulated genes allows to infer the transcription factors that underlie observed changes in gene expression. While such analyses constitute a central component of the in-silico characterization of transcriptional re...

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Bibliographic Details
Published in:Nucleic acids research 2010-07, Vol.38 (Web Server issue), p.W275-W280
Main Authors: Kiełbasa, Szymon M, Klein, Holger, Roider, Helge G, Vingron, Martin, Blüthgen, Nils
Format: Article
Language:English
Subjects:
Binding Sites
Gene Expression Regulation
Internet
Phylogeny
Promoter Regions, Genetic
Software
Transcription Factors - metabolism
Transcription, Genetic
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Summary:The analysis of putative transcription factor binding sites in promoter regions of coregulated genes allows to infer the transcription factors that underlie observed changes in gene expression. While such analyses constitute a central component of the in-silico characterization of transcriptional regulatory networks, there is still a lack of simple-to-use web servers able to combine state-of-the-art prediction methods with phylogenetic analysis and appropriate multiple testing corrected statistics, which returns the results within a short time. Having these aims in mind we developed TransFind, which is freely available at http://transfind.sys-bio.net/.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkq438