Higher Fibrinogen Levels Predict Progression of Coronary Artery Calcification in Adults with Type 1 Diabetes

Abstract Aim To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes. Methods Data from a prospective cohort - the Coronary Artery Calcification in Type 1 Diabetes Study - were evaluated. Fibrinogen levels at base...

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Bibliographic Details
Published in:Atherosclerosis 2010-06, Vol.210 (2), p.671-673
Main Authors: Rodrigues, T.C, Snell-Bergeon, J.K, Maahs, D.M, Kinney, G.L, Rewers, M
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcinosis - blood
Calcinosis - pathology
Cardiology. Vascular system
Cardiovascular
Cohort Studies
coronary artery calcification
Coronary Artery Disease - blood
Coronary Artery Disease - pathology
Coronary heart disease
Diabetes Complications - blood
Diabetes Mellitus, Type 1 - blood
Disease Progression
Female
fibrinogen
Fibrinogen - biosynthesis
Heart
Humans
Male
Medical sciences
Middle Aged
Prospective Studies
Risk Factors
type 1 diabetes
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Summary:Abstract Aim To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes. Methods Data from a prospective cohort - the Coronary Artery Calcification in Type 1 Diabetes Study - were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4 ± 0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by ≥2.5 mm3 or development of clinical coronary artery disease during the follow-up period. Results Fibrinogen levels were higher in progressors than in non-progressors (276 ± 61 mg/dl versus 259 ± 61 mg/dl, p = 0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile. Conclusions Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2009.12.034