5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems

Abstract To determine the role of central serotonin 5-HT3 receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT3 receptor agonists and antagonists. mCPBG and PBG (5-HT3...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2010-06, Vol.172 (1), p.42-52
Main Authors: Bartman, Michelle E, Wilkerson, Julia E.R, Johnson, Stephen M
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Afferent Pathways - physiology
Animals
Biguanides - pharmacology
Biological and medical sciences
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Hypoglossal Nerve - physiology
In Vitro Techniques
Indoles - pharmacology
Medical Education
Physical Stimulation - methods
Pulmonary/Respiratory
Receptors, Serotonin, 5-HT3 - physiology
Respiration - drug effects
Respiratory Center - cytology
Respiratory Center - physiology
Serotonin 5-HT3 Receptor Agonists
Serotonin 5-HT3 Receptor Antagonists
Serotonin Agents - pharmacology
Time Factors
Tropanes - pharmacology
Turtles - anatomy & histology
Vertebrates: respiratory system
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Summary:Abstract To determine the role of central serotonin 5-HT3 receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT3 receptor agonists and antagonists. mCPBG and PBG (5-HT3 receptor agonists) acutely increased XII burst frequency and regularity, and decreased bursts/episode. Tropisetron and MDL72222 (5-HT3 antagonists) increased bursts/episode, suggesting endogenous 5-HT3 receptor activation modulates burst timing in vitro . Tropisetron blocked all mCPBG effects, and the PBG-induced reduction in bursts/episode. Tropisetron application following mCPBG application did not reverse the long-lasting (2 h) mCPBG-induced decrease in bursts/episode. We conclude that endogenous 5-HT3 receptor activation regulates respiratory frequency, regularity, and episodicity in turtles and may induce a form of respiratory plasticity with the long-lasting changes in respiratory regularity.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2010.04.008