From Dendrite to Soma: Dynamic Routing of Inhibition by Complementary Interneuron Microcircuits in Olfactory Cortex

Diverse inhibitory pathways shape cortical information processing; however, the relevant interneurons recruited by sensory stimuli and how they impact principal cells are unclear. Here we show that two major interneuron circuits govern dynamic inhibition in space and time within the olfactory cortex...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2010-08, Vol.67 (3), p.452-465
Main Authors: Stokes, Caleb C.A., Isaacson, Jeffry S.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Brain
Cytoplasm - physiology
Dendrites - physiology
Experiments
Interneurons - physiology
Lymphocytes
Nerve Net - physiology
Neural Inhibition - physiology
Olfactory Pathways - physiology
Rats
Rats, Sprague-Dawley
Rodents
Routing
SYSNEURO
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Summary:Diverse inhibitory pathways shape cortical information processing; however, the relevant interneurons recruited by sensory stimuli and how they impact principal cells are unclear. Here we show that two major interneuron circuits govern dynamic inhibition in space and time within the olfactory cortex. Dendritic-targeting layer 1 interneurons receive strong input from the olfactory bulb and govern early-onset feedforward inhibition. However, this circuit is only transiently engaged during bursts of olfactory bulb input. In contrast, somatic-targeting layer 3 interneurons, recruited exclusively by recurrent excitation from pyramidal cells, produce late-onset feedback inhibition. Our results reveal two complementary interneuron circuits enforcing widespread inhibition, which shifts from the apical dendrites to somata of pyramidal cells during bursts of sensory input. ► Dendritic feedforward inhibition enhances cortical odor representations ► Somatic feedback inhibition outweighs recurrent excitation ► Routing of somatodendritic inhibition is dynamic
ISSN:0896-6273
1097-4199
1097-4199
DOI:10.1016/j.neuron.2010.06.029