Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways

We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2010-06, Vol.62 (3), p.201-203
Main Authors: Monobe, Manami, Ema, Kaori, Tokuda, Yoshiko, Maeda-Yamamoto, Mari
Format: Article
Language:English
Subjects:
Apoptosis
Biochemistry
Biological and medical sciences
Biomedicine
Biotechnology
Breast cancer
Brief Report
Caspase
Caspase inhibitors
Catechin
Cell differentiation
Chemistry
Chemistry and Materials Science
Dendritic cells
Epicatechin
Epigallocatechin gallate
Fundamental and applied biological sciences. Psychology
Green tea
Immune system
Immunoglobulins
Kinases
Lymphatic system
Macrophages
Phagocytes
Phagocytosis
Polyphenols
Pyrogallol
Signal transduction
Tea
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Summary:We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and +C, increased the phagocytic activity of macrophage-like cells, and a caspase inhibitor significantly inhibited phagocytic activities. These results suggest that the pyrogallol-type structure in green tea polyphenols may be important for enhancement of the phagocytic activity through caspase signaling pathways.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-010-9280-2