Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy

Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation,...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2010-08, Vol.106 (3), p.360-368
Main Authors: Turer, Aslan T., MD, MHS, Hill, Joseph A., MD, PhD
Format: Article
Language:English
Subjects:
Cardiac Surgical Procedures - adverse effects
Cardiology
Cardiovascular
Heart Arrest, Induced - adverse effects
Humans
Ischemia
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Pathogenesis
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. The purposes of this review are to examine the current state of understanding of ischemia-reperfusion injury, as well as to highlight recent interventions aimed at this heretofore elusive target. In conclusion, despite its complexity our ongoing efforts to mitigate this form of injury should not be deterred, because nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2010.03.032