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Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India
Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India. Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg...
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| Published in: | Transfusion medicine (Oxford, England) England), 2010-12, Vol.20 (6), p.414-420 |
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| container_title | Transfusion medicine (Oxford, England) |
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| creator | Jagannathan, L. Chaturvedi, M. Mudaliar, S. Kamaladoss, T. Rice, M. Murphy, E. L. |
| description | Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.
Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.
Methods/Materials: Using a case‐cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.
Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first‐time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60).
Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India. |
| doi_str_mv | 10.1111/j.1365-3148.2010.01032.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2957532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>815539596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5432-e9b28fd5ff7c674a64710b86883f8096ab3851d47309a17793b32596b9e9a07a3</originalsourceid><addsrcrecordid>eNqNkVtvEzEQhS0EoqHwF5DfeGGDL-u1_QASCW2p1HJTERI8jLy7duJ0Y6f2pqT_nl1SInjD0sjWzPnOWDoIYUqmdDivVlPKK1FwWqopI0N3KM6muwdochg8RBOihSqkkOoIPcl5RQjlTLPH6IgRySot-AT9-OLzNXam6WPK2MWEm2WKwTd4aTem973PeIZvfdpm7IOzTe9jwGYdwwLXXYwtbmMYUR_wzISF6WKyL_F5aL15ih4502X77P4-Rl9PT67m74uLj2fn87cXRSNKzgqra6ZcK5yTTSVLU5WSklpVSnGniK5MzZWgbSk50YZKqXnNmdBVra02RBp-jN7sfTfbem3bxoY-mQ42ya9NuoNoPPw7CX4Ji3gLTAspOBsMXtwbpHiztbmHtc-N7ToTbNxmUFQIroeVg1LtlU2KOSfrDlsogTEaWMGYAIwJwBgN_I4GdgP6_O9fHsA_WQyC13vBT9_Zu_82hqvLk_E18MWe97m3uwNv0jVUkksB3z6cwfzdp8_l6eUMvvNfn2msng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>815539596</pqid></control><display><type>article</type><title>Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India</title><source>Wiley</source><creator>Jagannathan, L. ; Chaturvedi, M. ; Mudaliar, S. ; Kamaladoss, T. ; Rice, M. ; Murphy, E. L.</creator><creatorcontrib>Jagannathan, L. ; Chaturvedi, M. ; Mudaliar, S. ; Kamaladoss, T. ; Rice, M. ; Murphy, E. L.</creatorcontrib><description>Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.
Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.
Methods/Materials: Using a case‐cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.
Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first‐time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60).
Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.</description><identifier>ISSN: 0958-7578</identifier><identifier>EISSN: 1365-3148</identifier><identifier>DOI: 10.1111/j.1365-3148.2010.01032.x</identifier><identifier>PMID: 20726953</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Barbering ; Blood donors ; Blood Donors - statistics & numerical data ; Chronic infection ; Cohort Studies ; Environmental Exposure ; Female ; haematology ; Hepatitis B virus ; Hepatitis B, Chronic - epidemiology ; Humans ; India - epidemiology ; Male ; Middle Aged ; Risk Factors ; Risk-Taking ; Rural Population ; Socioeconomic Factors ; Surveys and Questionnaires ; Volunteers ; Young Adult</subject><ispartof>Transfusion medicine (Oxford, England), 2010-12, Vol.20 (6), p.414-420</ispartof><rights>2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society</rights><rights>2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5432-e9b28fd5ff7c674a64710b86883f8096ab3851d47309a17793b32596b9e9a07a3</citedby><cites>FETCH-LOGICAL-c5432-e9b28fd5ff7c674a64710b86883f8096ab3851d47309a17793b32596b9e9a07a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20726953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jagannathan, L.</creatorcontrib><creatorcontrib>Chaturvedi, M.</creatorcontrib><creatorcontrib>Mudaliar, S.</creatorcontrib><creatorcontrib>Kamaladoss, T.</creatorcontrib><creatorcontrib>Rice, M.</creatorcontrib><creatorcontrib>Murphy, E. L.</creatorcontrib><title>Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India</title><title>Transfusion medicine (Oxford, England)</title><addtitle>Transfus Med</addtitle><description>Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.
Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.
Methods/Materials: Using a case‐cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.
Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first‐time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60).
Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.</description><subject>Adult</subject><subject>Barbering</subject><subject>Blood donors</subject><subject>Blood Donors - statistics & numerical data</subject><subject>Chronic infection</subject><subject>Cohort Studies</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>haematology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Risk-Taking</subject><subject>Rural Population</subject><subject>Socioeconomic Factors</subject><subject>Surveys and Questionnaires</subject><subject>Volunteers</subject><subject>Young Adult</subject><issn>0958-7578</issn><issn>1365-3148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkVtvEzEQhS0EoqHwF5DfeGGDL-u1_QASCW2p1HJTERI8jLy7duJ0Y6f2pqT_nl1SInjD0sjWzPnOWDoIYUqmdDivVlPKK1FwWqopI0N3KM6muwdochg8RBOihSqkkOoIPcl5RQjlTLPH6IgRySot-AT9-OLzNXam6WPK2MWEm2WKwTd4aTem973PeIZvfdpm7IOzTe9jwGYdwwLXXYwtbmMYUR_wzISF6WKyL_F5aL15ih4502X77P4-Rl9PT67m74uLj2fn87cXRSNKzgqra6ZcK5yTTSVLU5WSklpVSnGniK5MzZWgbSk50YZKqXnNmdBVra02RBp-jN7sfTfbem3bxoY-mQ42ya9NuoNoPPw7CX4Ji3gLTAspOBsMXtwbpHiztbmHtc-N7ToTbNxmUFQIroeVg1LtlU2KOSfrDlsogTEaWMGYAIwJwBgN_I4GdgP6_O9fHsA_WQyC13vBT9_Zu_82hqvLk_E18MWe97m3uwNv0jVUkksB3z6cwfzdp8_l6eUMvvNfn2msng</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Jagannathan, L.</creator><creator>Chaturvedi, M.</creator><creator>Mudaliar, S.</creator><creator>Kamaladoss, T.</creator><creator>Rice, M.</creator><creator>Murphy, E. L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201012</creationdate><title>Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India</title><author>Jagannathan, L. ; Chaturvedi, M. ; Mudaliar, S. ; Kamaladoss, T. ; Rice, M. ; Murphy, E. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5432-e9b28fd5ff7c674a64710b86883f8096ab3851d47309a17793b32596b9e9a07a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Barbering</topic><topic>Blood donors</topic><topic>Blood Donors - statistics & numerical data</topic><topic>Chronic infection</topic><topic>Cohort Studies</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>haematology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Risk-Taking</topic><topic>Rural Population</topic><topic>Socioeconomic Factors</topic><topic>Surveys and Questionnaires</topic><topic>Volunteers</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jagannathan, L.</creatorcontrib><creatorcontrib>Chaturvedi, M.</creatorcontrib><creatorcontrib>Mudaliar, S.</creatorcontrib><creatorcontrib>Kamaladoss, T.</creatorcontrib><creatorcontrib>Rice, M.</creatorcontrib><creatorcontrib>Murphy, E. L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transfusion medicine (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jagannathan, L.</au><au>Chaturvedi, M.</au><au>Mudaliar, S.</au><au>Kamaladoss, T.</au><au>Rice, M.</au><au>Murphy, E. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India</atitle><jtitle>Transfusion medicine (Oxford, England)</jtitle><addtitle>Transfus Med</addtitle><date>2010-12</date><risdate>2010</risdate><volume>20</volume><issue>6</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>0958-7578</issn><eissn>1365-3148</eissn><abstract>Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.
Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.
Methods/Materials: Using a case‐cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.
Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first‐time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60).
Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20726953</pmid><doi>10.1111/j.1365-3148.2010.01032.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transfusion medicine (Oxford, England), 2010-12, Vol.20 (6), p.414-420 |
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| source | Wiley |
| subjects | Adult Barbering Blood donors Blood Donors - statistics & numerical data Chronic infection Cohort Studies Environmental Exposure Female haematology Hepatitis B virus Hepatitis B, Chronic - epidemiology Humans India - epidemiology Male Middle Aged Risk Factors Risk-Taking Rural Population Socioeconomic Factors Surveys and Questionnaires Volunteers Young Adult |
| title | Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India |
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