Circadian Disruption, Per3, and Human Cytokine Secretion

Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscop...

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Bibliographic Details
Published in:Integrative cancer therapies 2009-12, Vol.8 (4), p.329-336
Main Authors: Guess, Jaclyn, Burch, James B., Ogoussan, Kisito, Armstead, Cheryl A., Hongmei Zhang, Wagner, Sara, Hebert, James R., Wood, Patricia, Youngstedt, Shawn D., Hofseth, Lorne J., Singh, Udai P., Dawen Xie, Hrushesky, William J. M.
Format: Article
Language:English
Subjects:
Chronobiology Disorders - blood
Chronobiology Disorders - genetics
Colonoscopy
Cytokines - blood
Depression - blood
Depression - genetics
Fatigue - blood
Fatigue - genetics
Genetic Variation
Genotype
Humans
Inflammation - blood
Inflammation - genetics
Interleukin-6 - blood
Male
Middle Aged
Period Circadian Proteins - genetics
Polymorphism, Genetic
Sleep Deprivation - blood
Sleep Deprivation - genetics
Surveys and Questionnaires
Tandem Repeat Sequences
Tumor Necrosis Factor-alpha - blood
Vascular Endothelial Growth Factor A - blood
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Summary:Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.
ISSN:1534-7354
1552-695X
DOI:10.1177/1534735409352029