6β-Acetamido-5α-hydroxy-cholestan-3β-yl acetate

The title steroid, C(31)H(53)NO(4), was prepared from the corresponding 5α,6α-epoxy-cholestane. The conformation of the six-membered rings is close to a chair form, while the five-membered ring adopts a twist conformation. The hydroxyl and acetamide groups are in axial positions. The nucleophilic sp...

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Bibliographic Details
Published in:Acta crystallographica. Section E, Structure reports online Structure reports online, 2008-11, Vol.64 (Pt 12), p.o2303-o2303
Main Authors: Pinto, R M A, Ramos Silva, M, Matos Beja, A, Salvador, J A R, Paixão, J A
Format: Article
Language:English
Subjects:
Organic Papers
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Summary:The title steroid, C(31)H(53)NO(4), was prepared from the corresponding 5α,6α-epoxy-cholestane. The conformation of the six-membered rings is close to a chair form, while the five-membered ring adopts a twist conformation. The hydroxyl and acetamide groups are in axial positions. The nucleophilic species bound to the steroid nucleus at position 6 by the β-face, whereas the hydroxyl group at position 5 has α-orientation. All rings are trans-fused. The crystal packing shows that the mol-ecules related by twofold symmetry exist as O-H⋯O hydrogen-bonded dimers.
ISSN:1600-5368
1600-5368
DOI:10.1107/S160053680803568X